结节硬化症相关性癫痫治疗进展

doi:10.12372/jcp.2022.21e1280

Abstract

Abstract:

Patients with tuberous sclerosis complex (TSC) are at high risk of epilepsy, most of which begins in infancy. Excessive activation of mTOR signaling pathway and focal cortical dysplasia are important mechanisms for TSC-related epilepsy. Epileptiform abnormal electrical brain activity can effectively predict the occurrence of subsequent epileptic seizure. Electroencephalogram is the main method of recording epileptic abnormal brain electrical activity. Prophylactic use of vigabatrin will effectively inhibit the chance of TSC-related epilepsy and protect neurodevelopment. Antiepileptic drugs, mTOR inhibitors, epileptic surgery, ketogenic diet and vagal nerve stimulation are commonly used therapeutic schedules for TSC-related epilepsy. In this paper, the latest research progress on the treatment of TSC-related epilepsy will be described.

Key words: tuberous sclerosis complex, epilepsy, therapy

Reviewer: TIAN Qilong, Reviser: WANG Julei. Research progress in the treatment of epilepsy associated with tuberous sclerosis complex[J].Journal of Clinical Pediatrics, 2022, 40(4): 311-315.

References 46

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Research progress in the treatment of epilepsy associated with tuberous sclerosis complex

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