运动康复对哮喘患儿嗜酸性粒细胞炎症表达的影响

doi:10.12372/jcp.2022.22e0129

Abstract

Abstract:

Objective To explore the effect of aerobic exercise on eosinophil inflammation in children with allergic asthma. Methods A total of 101 children with dust mite-sensitized bronchial asthma in remission from June 2019 to May 2021 were enrolled. Among them, 50 cases in the control group followed the GINA regimen were given comprehensive treatment based on inhaled corticosteroids (ICS), and 51 cases in the treatment group practiced aerobic exercise on top of the GINA regimen. Blood eosinophil count (EOS), eosinophil cationic protein (ECP), interleukin-13 (IL-13) and fractional exhaled nitric oxide (FeNO) at 3 months, 1 year, and high-incidence seasons after treatment and asthma control after 1 year of follow-up in the two groups of children were evaluated. Results A total of 101 children with asthma in remission were included in the study. There were 51 cases in the treatment group, including 31 males and 20 females, aged (8.0±2.0) years, with mild persistent asthma in 32 cases and moderate persistent asthma in 19 cases. The control group consisted of 50 cases, 29 males and 21 females, aged (8.5±2.7) years, with 28 cases of mild persistent asthma and 22 cases of moderate persistent asthma. The EOS, FeNO, ECP and IL-13 in the treatment group were lower than those in the control group in 3 months, 1 year and high-incidence season, and the differences were statistically significant (P<0.05). The average annual total dose of ICS in the treatment group was less than that in the control group, and the difference was statistically significant (P<0.05). There was a statistically significant difference between the treatment group and the control group in the distribution of acute attacks of asthma (P<0.05), and the proportion of children with asthma in the treatment group was lower. Conclusions Under the premise of standardized control and treatment of ICS in children with asthma in remission, the aerobic exercise has positive function on effectively reducing the expression of airway eosinophilic inflammation, reducing the dosage of ICS, and reducing acute asthma attacks.

Key words: allergic asthma, aerobic exercise, eosinophil inflammation, child

TAN Yongqiang, LIU Haipei, SHI Yanrong. Effect of aerobic exercise on eosinophil inflammation in children with allergic asthma[J].Journal of Clinical Pediatrics, 2022, 40(8): 586-590.

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References 21

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时点	组别	EOS计数×10⁹·L^-1	FeNO/ppb·L^-1	ECP/ng·mL^-1	IL-13/pg·mL^-1
研究开始	对照组	0.5(0.5~0.7)	20.5(16.0~26.0)	3.7±0.8	79.8±16.7
	治疗组	0.5(0.4~0.7)	21.0(16.0~25.0)	3.6±0.9	78.4±17.4
	统计量	Z=0.56	Z=0.27	t=0.44	t=0.40
	P	0.575	0.791	0.665	0.688
随访3个月	对照组	0.5(0.5~0.7)	20.5(15.0~25.0)	3.7±0.8	80.2±17.3
	治疗组	0.4(0.4~0.6)	15.0(12.0~21.0)	3.3±0.8	72.7±18.4
	统计量	Z=2.30	Z=2.94	t=2.45	t=2.10
	P	0.021	0.003	0.016	0.038
随访1年	对照组	0.6(0.4~0.7)	20.0(15.0~27.0)	3.6±0.8	77.5±16.5
	治疗组	0.4(0.3~0.6)	18.0(13.0~21.0)	3.2±0.8	70.6±13.7
	统计量	Z=2.47	Z=2.22	t=2.35	t=2.29
	P	0.013	0.027	0.021	0.024
高发季节	对照组	0.7(0.5~0.8)	25.5(19.0~37.5)	4.2±1.1	87.5±16.9
	治疗组	0.6(0.5~0.7)	21.0(18.0~23.0)	3.6±0.8	76.7±16.3
	统计量	Z=2.68	Z=2.98	t=2.92	t=3.26
	P	0.007	0.003	0.004	0.002

组别	例数	人年均ICS总用量/mg	急性发作/次			控制水平
组别	例数	人年均ICS总用量/mg	0	1、2	>2	完全控制	部分控制	未控制
对照组	50	30.4(18.3~36.5)	30(60.0)	17(34.0)	3(6.0)	40(80.0)	8(16.0)	2(4.0)
治疗组	51	18.3(12.1~25.2)	42(82.4)	9(17.6)	0(0)	45(88.2)	6(11.8)	0(0)
统计量		Z=3.40	-			-
P		0.001	0.019¹⁾			0.311¹⁾

Effect of aerobic exercise on eosinophil inflammation in children with allergic asthma

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