Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (8): 634-640.doi: 10.12372/jcp.2023.22e0820

• Continuing Medical Education • Previous Articles    

Research progress on the role of intestinal flora in sepsis

WANG Yanfei, TAN Linhua   

  1. Department of Surgical Intensive Care Unit, Children's Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou 310052, Zhejiang, China
  • Received:2022-06-13 Online:2023-08-15 Published:2023-08-10

Abstract:

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection which affects children's health. The intestinal flora play an important regulatory role in host metabolism and immunity and are associated with a variety of diseases. Studies have shown that sepsis and clinical treatments can lead to intestinal flora imbalance in children, which further affects the prognosis of the disease; while healthy intestinal flora can reduce the susceptibility of children to sepsis and improve the survival of sepsis, and ameliorate the damage to the function of organs. This article reviews the related research on intestinal flora and sepsis, in order to contribute to the prevention and treatment of sepsis in children.

Key words: sepsis, intestinal flora, metabolism, child