Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (8): 584-588.doi: 10.12372/jcp.2023.22e0925
• Infectious Disease • Previous Articles Next Articles
Received:
2022-07-04
Published:
2023-08-15
Online:
2023-08-10
Contact:
LIU Quanbo
E-mail:liuqb1223@sina.com
XU Beixue, LIU Quanbo. Clinical analysis of 195 children with invasive pulmonary fungal infection[J].Journal of Clinical Pediatrics, 2023, 41(8): 584-588.
"
侵袭性因素 | 新生儿组(n=52) | 婴幼儿组(n=79) | 年长儿组(n=64) | χ2值 | P |
---|---|---|---|---|---|
头孢类抗生素 | 36(69.2) | 46(58.2) | 39(60.9) | 1.66 | 0.432 |
碳青霉烯类抗生素 | 38(73.1) | 54(68.4) | 41(64.1) | 1.08 | 0.586 |
β-内酰胺酶抑制剂抗生素 | 37(71.2) | 47(59.5) | 36(56.3) | 2.93 | 0.234 |
糖肽类抗生素 | 22(42.3) | 18(22.8) | 19(29.7) | 5.68 | 0.057 |
上述抗生素两联使用 | 33(63.5) | 32(40.5) | 22(34.4) | 10.73 | 0.005 |
深静脉置管 | 28(53.8) | 29(36.7) | 23(35.9) | 4.83 | 0.093 |
有创机械通气 | 32(61.5) | 40(50.6) | 32(50.0) | 1.92 | 0.393 |
血液净化或透析 | 1(1.9) | 4(5.1) | 15(23.4) | - | <0.0011) |
胸腔穿刺 | 6(11.5) | 11(13.9) | 9(14.1) | 0.20 | 0.929 |
留置胃管 | 42(80.8) | 42(53.2) | 34(53.1) | 12.18 | 0.002 |
糖皮质激素 | 2(3.8) | 32(40.5) | 32(50.0) | 29.93 | <0.001 |
化疗或其他免疫抑制剂 | 0(0) | 10(12.7) | 23(35.9) | - | <0.0011) |
胃肠外营养 | 48(92.3) | 22(27.8) | 16(25.0) | 66.96 | <0.001 |
"
念珠菌 | 株数 | 5-氟胞嘧啶 | 两性霉素B | 氟康唑 | 伊曲康唑 | 伏立康唑 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S | R | S | R | S | Ⅰ | R | S | Ⅰ | R | S | Ⅰ | R | ||
白色假丝 酵母菌 | 208 | 202(97.1) | 6(2.9) | 208(100) | 0(0) | 188(90.4) | 7(3.4) | 13(6.2) | 180(86.5) | 13(6.3) | 14(6.7) | 191(91.8) | 3(1.4) | 14(6.7) |
近平滑假丝 酵母菌 | 16 | 16(100) | 0(0) | 16(100) | 0(0) | 13(81.3) | 3(18.8) | 0(0) | 15(93.8) | 1(6.3) | 0(0) | 15(93.8) | 1(6.3) | 0(0) |
热带假丝 酵母菌 | 22 | 22(100) | 0(0) | 22(100) | 0(0) | 21(95.5) | 0(0) | 1(4.5) | 18(81.8) | 3(13.6) | 1(4.5) | 19(86.4) | 1(4.5) | 2(9.1) |
光滑球拟 酵母菌 | 11 | 11(100) | 0(0) | 11(100) | 0(0) | 1(9.1) | 10(90.9) | 0(0) | 1(9.1) | 10(90.9) | 0(0) | 9(81.8) | 2(18.2) | 0(0) |
葡萄牙假丝 酵母菌 | 3 | 3(100) | 0(0) | 0(0) | 3(100) | 3(100) | 0(0) | 0(0) | 3(100 ) | 0(0) | 0(0) | 3(100) | 0(0) | 0(0) |
季也蒙假丝 酵母菌 | 1 | 1(100) | 0(0) | 1(100) | 0(0) | 0(0) | 1(100) | 0(0) | 0(0) | 1(100) | 0(0) | - | - | - |
挪威假丝 酵母菌 | 2 | 0(0) | 2(100) | 1(50) | 1(50) | 1(50) | 1(50) | 0(0) | 0(0) | 2(100) | 0(0) | 2(100) | 0(0) | 0(0) |
产朊假丝 酵母菌 | 1 | 1(100) | 0(0) | 1(100) | 0(0) | 1(100) | 0(0) | 0(0) | 1(100) | 0(0) | 0(0) | 1(100) | 0(0) | 0(0) |
[1] |
Schwartz S, Kontoyiannis DP, Harrison T, et al. Advances in the diagnosis and treatment of fungal infections of the CNS[J]. Lancet Neurol, 2018, 17(4): 362-372.
doi: S1474-4422(18)30030-9 pmid: 29477506 |
[2] | Fracchiolla NS, Sciumè M, Orofino N, et al. Epidemiology and treatment approaches in management of invasive fungal infections in hematological malignancies: results from a single-centre study[J]. PLoS One, 2019, 14(5): e0216715. |
[3] |
Hage CA, Carmona EM, Epelbaum O, et al. Microbiological laboratory testing in the diagnosis of fungal infections in pulmonary and critical care practice. An Official American Thoracic Society Clinical Practice Guideline[J]. Am J Respir Crit Care Med, 2019, 200(5): 535-550.
doi: 10.1164/rccm.201906-1185ST |
[4] | 中华医学会儿科学分会, 中华儿科杂志编辑委员会. 儿童侵袭性肺部真菌感染临床实践专家共识(2022版)[J]. 中华儿科杂志, 2022, 60(4): 274-282. |
[5] | Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America[J]. Clin Infect Dis, 2016, 62(4): e1-e50. |
[6] | Ullmann AJ, Aguado JM, Arikan-Akdagli S, et al. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline[J]. Clin Microbiol Infect, 2018, 24(Suppl 1): e1-e38. |
[7] |
Hsu JF, Lai MY, Lee CW, et al. Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates[J]. BMC Infect Dis, 2018, 18(1): 194.
doi: 10.1186/s12879-018-3100-2 |
[8] |
Egger M, Hoenigl M, Thompson GR 3rd, et al. Let's talk about sex characteristics-As a risk factor for invasive fungal diseases[J]. Mycoses, 2022, 65(6): 599-612.
doi: 10.1111/myc.v65.6 |
[9] |
Steinbach WJ, Roilides E, Berman D, et al. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates[J]. Pediatr Infect Dis J, 2012, 31(12): 1252-1257.
doi: 10.1097/INF.0b013e3182737427 pmid: 22982980 |
[10] |
Luo J, Chen J, Li Q, et al. Differences in clinical cha-racteristics and therapy of neonatal acute respiratory distress syndrome (ARDS) and respiratory distress syndrome (RDS): a retrospective analysis of 925 cases[J]. Med Sci Monit, 2019, 25: 4992-4998.
doi: 10.12659/MSM.915213 |
[11] |
Yamin DH, Husin A, Harun A. Risk factors of Candida parapsilosis catheter-related bloodstream infection[J]. Front Public Health, 2021, 9: 631865.
doi: 10.3389/fpubh.2021.631865 |
[12] |
Matic T, Novak M, Braovac D, et al. Characteristics, risk factors and predictors for candidemia in the pediatric intensive care unit at the University Hospital Centre Zagreb in Croatia: a 9-year retrospective study[J]. Pediatr Infect Dis J, 2021, 40(11): 981-986.
doi: 10.1097/INF.0000000000003225 pmid: 34108407 |
[13] | Zaoutis TE, Prasad PA, Localio AR, et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention[J]. Clin Infect Dis, 2010, 51(5):e38-e45. |
[14] |
Wang Q, Liu Y, Han L, et al. Risk factors for acute stroke-associated pneumonia and prediction of neutrophil-to-lymphocyte ratios[J]. Am J Emerg Med, 2021, 41: 55-59.
doi: 10.1016/j.ajem.2020.12.036 pmid: 33387929 |
[15] | 梁若冰. 早产儿侵袭性真菌感染的临床特点分析[D]. 长春: 吉林大学, 2016. |
[16] |
Kobayashi R, Hori D, Sano H, et al. Risk factors for invasive fungal infection in children and adolescents with hematologic and malignant diseases: a 10-year analysis in a single institute in Japan[J]. Pediatr Infect Dis J, 2018, 37(12): 1282-1285.
doi: 10.1097/INF.0000000000002010 pmid: 30408007 |
[17] |
Johnson BN, Fierro JL, Panitch HB. Pulmonary manifestations of congenital heart disease in children[J]. Pediatr Clin North Am, 2021, 68(1): 25-40.
doi: 10.1016/j.pcl.2020.09.001 |
[18] | 吴婷婷, 刘艳, 苏堂枫, 等. 儿童肺部侵袭性真菌感染临床特点分析[J]. 中华医院感染学杂志, 2015, 25(22): 3. |
[19] |
Peng L, Xu Z, Huo Z, et al. New insights into the clinical characteristics and prognostic factors of pulmonary fungal infections from a retrospective study in Southwestern China[J]. Infect Drug Resist, 2018, 11: 307-315.
doi: 10.2147/IDR.S157030 pmid: 29551904 |
[20] |
Cortegiani A, Misseri G, Chowdhary A. What's new on emerging resistant Candida species[J]. Intensive Care Med, 2019, 45(4): 512-515.
doi: 10.1007/s00134-018-5363-x pmid: 30191295 |
[1] | LUO Mingjing, YU Jiaming, WANG Xiaodong, ZHANG Xiaoling, YU Yue, ZHANG Yu, WEN Feiqiu, LIU Sixi. Clinical analysis of invasive fungal disease secondary to allogeneic hematopoietic stem cell transplantation in 424 children with thalassemia [J]. Journal of Clinical Pediatrics, 2025, 43(1): 21-28. |
[2] | LIU Dongxia, JIN Rong, LIN Rongjun. Risk factors analysis of severe refractory Mycoplasma pneumoniae pneumonia complicated with bronchitis obliterans in children [J]. Journal of Clinical Pediatrics, 2025, 43(1): 29-34. |
[3] | ZHONG Jinhong, WANG Can, CHEN Fang. Progress in the research of infantile fiberoptic bronchoscopy sedation [J]. Journal of Clinical Pediatrics, 2025, 43(1): 50-55. |
[4] | JIANG Weiqin, WANG Jing, CHENG Anna, CHEN Tingting, HUANG Yujuan. Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures [J]. Journal of Clinical Pediatrics, 2025, 43(1): 8-13. |
[5] | QIU Xiu, WEI Dongmei, LIN Shanshan, XIA Huimin, ZHOU Wenhao. Principles and practice of the Born in Guangzhou Cohort Study [J]. Journal of Clinical Pediatrics, 2024, 42(9): 747-752. |
[6] | FAN Jianxia. The origins and development of the healthy life trajectory program: a cohort of community-family-mother-child multidimensional interventions for overweight and obesity in children [J]. Journal of Clinical Pediatrics, 2024, 42(9): 768-773. |
[7] | JIANG Tao, LI Shuangjie, TANG Lian, OUYANG Wenxian. Immunobiological properties of peripheral blood MAIT cells in children with chronic hepatitis B [J]. Journal of Clinical Pediatrics, 2024, 42(9): 787-790. |
[8] | ZHOU Jie, LIU Keqiang, WANG Jinling, WANG Ying. Megacystis-microcolon-intestinal hypoperistalsis syndrome caused by MYH11 elongating mutation : a case report and literatures review [J]. Journal of Clinical Pediatrics, 2024, 42(9): 798-804. |
[9] | CHU Sijia, TANG Jihong. Research progress of central nervous system injury associated with pediatric acute lymphoblastic leukemia and its treatment [J]. Journal of Clinical Pediatrics, 2024, 42(9): 811-816. |
[10] | DING Yaping, XIA Shanshan, ZHANG Chenmei. Interpretation of “2023 Children’s Renal Nutrition Working Group Clinical Practice Recommendations: Nutritional Management of Children with Acute Kidney Injury” [J]. Journal of Clinical Pediatrics, 2024, 42(8): 667-672. |
[11] | LI Yirong, LI Huiping, GAO Jingyu, XIAO Yuhua, CHEN Xiaomin, LU Yanling, ZHAO Nana, FENG Xiaoqin. Comparison of different doses of cytarabine for induction chemotherapy in children with acute myeloid leukemia in FLAG-IDA regimen [J]. Journal of Clinical Pediatrics, 2024, 42(8): 673-677. |
[12] | HUANG Bo, DONG Yanying, SONG Linlan. Clinical characteristics of 348 children with infectious mononucleosis [J]. Journal of Clinical Pediatrics, 2024, 42(8): 678-683. |
[13] | WANG Dan, SHAO Jingbo, LI Hong, ZHANG Na, ZHU Jiashi, FU Pan, WANG Zhen. Clinical analysis of 38 cases of hematological malignancies complicated with tumor lysis syndrome in children [J]. Journal of Clinical Pediatrics, 2024, 42(8): 684-690. |
[14] | MA Yan, WEI Xingjiao, BAI Hua, ZHANG Yan, TIAN Xinmin, Aqsa Ahmad, LIANG Lijun. Analysis of etiological composition and clinical features of stage 5 chronic kidney disease in children in a tertiary hospital in western China [J]. Journal of Clinical Pediatrics, 2024, 42(8): 697-703. |
[15] | WANG Ye, ZHANG Linlin, CHI Zuofei, SUN Ruowen, JIANG Zehui, XU Gang. A case of clinical report of T-lymphoblastic lymphoma secondary to acute promyelocytic leukemia in children [J]. Journal of Clinical Pediatrics, 2024, 42(8): 722-727. |
Viewed | ||||||||||||||||||||||||||||||||||||||||||||||||||
Full text 518
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||
Abstract 295
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||
Cited |
|
|||||||||||||||||||||||||||||||||||||||||||||||||
Shared | ||||||||||||||||||||||||||||||||||||||||||||||||||
|