Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (8): 571-577.doi: 10.12372/jcp.2023.23e0416

• Expert Review • Previous Articles     Next Articles

Strategies for the diagnosis, treatment, and management of invasive fungal infections in children with hematologic neoplasms

SHEN Nan, DU Bailu   

  1. Department of Infectious Disease, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2023-05-14 Online:2023-08-15 Published:2023-08-10


Invasive fungal disease (IFD) is one of the most common types of infection in the treatment of hematologic malignancies and has a significant impact on the prognosis of pediatric patients with hematologic malignancies. In recent years, with the development of pathogen molecular detection techniques and the application of new antifungal drugs, the prognosis of IFD in pediatric patients with hematologic malignancies has been greatly improved. However, challenges such as diagnostic difficulties, complex disease conditions, and the selection of treatment drugs still exist. This article summarizes the current research progress and the latest diagnostic and therapeutic guidelines to elucidate the risk factors, clinical features, treatment strategies, and prognosis of IFD in pediatric patients with hematologic malignancies, aiming to better assist pediatricians in understanding the prevention, management, and treatment of IFD in pediatric patients with hematologic malignancies.

Key words: invasive fungal disease, hematologic malignancies, diagnostic and therapeutic guidelines, treatment, child