Abstract:

Objective To compare the effects of volume guaranteed (VG) ventilation and pressure controlled (PC) ventilation in premature infants with respiratory distress syndrome (RDS). Methods RDS premature infants with gestational age <32 weeks or birth weight <1500g and requiring invasive mechanical ventilation from March 2017 to April 2021 were prospectively enrolled in the study. Patients were divided into VG group and PC group by simple random method. Before extubation, ventilator parameters, arterial blood gas, invasive mechanical ventilation time, total respiratory support time, average hospital stay, incidence of complications and mortality were compared between the two groups. Results Finally, 79 premature infants with RDS (46 boys and 33 girls) completed the study, the average gestational age was (30.1±1.2) weeks and the average birth weight was (1239.0±158.0) g. There were 36 patients in the VG group and 43 patients in the PC group. Compared with the PC group, the average airway pressure before extubation was lower in the VG group, and invasive mechanical ventilation time, total respiratory support time and average hospital stay were shortened, with statistically significant differences (P<0.05). Conclusions For premature infants with RDS, the VG mode may be a safer and more effective mode of mechanical ventilation. However, multi-center clinical trials with large sample sizes are needed to verify the results of our current study.

Key words: volume guaranteed ventilation, respiratory distress syndrome, preterm infant