儿童哮喘合并阻塞性睡眠呼吸暂停低通气综合征高危人群的临床特点

doi:10.12372/jcp.2024.23e1164

Abstract

Abstract:

Objective This study aimed to explore the clinical characteristics of children with asthma who were at high risk of developing obstructive sleep apnea syndrome (OSAS). Methods A questionnaire survey among outpatient pediatric asthmatic children were conducted from September 2019 to January 2021. Children were categorized into an OSAS high-risk group and a control group based on responses to the questionnaire. Results A total of 200 asthmatic children were included, with 41.00% falling into the OSAS high-risk category. More uncontrolled asthmatic patients were found OSAS high-risk children (60.00% vs. 36.25%, χ²=7.46, P=0.006). Additionally, children in the OSAS high-risk group experienced a higher incidence of nocturnal asthma attacks (20.73% vs. 6.78%, P<0.05) and exercise-induced asthma symptoms (26.83% vs. 13.56%, P<0.05). The prevalence of adenoid hypertrophy was also greater in the OSAS high-risk group (35.37% vs. 8.47%, P<0.05), along with more severe symptoms of allergic rhinitis (P<0.05). Conclusion Children with asthma who are at high risk for OSAS are more likely to exhibit poorly controlled asthma, severe symptoms of allergic rhinitis, and a higher incidence of adenoid hypertrophy.

Key words: asthma, obstructive sleep apnea syndrome, child

ZHU Wenjing, GU Qinglong, LIU Chuanhe, SHA Li, HUANG Guimin, LU Yingxia, ZHAO Jing, CHEN Yuzhi. Characteristic of obstructive sleep apnea hypopnea syndrome high risk population in children with bronchial asthma[J].Journal of Clinical Pediatrics, 2024, 42(11): 922-926.

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References 24

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项目	OSAS高危组(n=82)	对照组(n=118)	统计量	P
年龄($\bar{x} \pm s$)/岁	6.96±2.00	7.70±2.10	t=2.44	0.016
男童[n(%)]	57(69.51)	81(68.64)	χ²=0.12	0.896
身高($\bar{x} \pm s$)/cm	127.32±14.10	130.76±13.60	t=1.74	0.084
体重($\bar{x} \pm s$)/kg	30.56±12.70	30.88±12.80	t=0.17	0.863
BMI[M(P₂₅~P₇₅)]/kg·m^-2	17.01(14.91~20.11)	16.47(14.68~19.04)	U=4 317.00	0.196

项目	OSAS高危组(n=82)	对照组(n=118)	统计量	P
哮喘日间>2次[n(%)]	21(25.61)	25(21.19)	χ²=0.53	0.465
夜间哮喘症状[n(%)]	17(20.73)	8(6.78)	χ²=8.61	0.003
哮喘活动受限[n(%)]	22(26.83)	16(13.56)	χ²=5.34	0.019
VAS评分[M(P₂₅~P₇₅)]
鼻塞	60(40~80)	30(0~50)	U=2 060.00	<0.001
鼻痒	40(5~70)	20(0~50)	U=3 036.50	0.003
喷嚏	30(10~50)	20(0~40)	U=3 045.50	0.003
流涕	20(0~60)	10(0~30)	U=2 833.50	<0.001

Characteristic of obstructive sleep apnea hypopnea syndrome high risk population in children with bronchial asthma

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