Journal of Clinical Pediatrics ›› 2025, Vol. 43 ›› Issue (10): 798-802.doi: 10.12372/jcp.2025.24e0974

• Literature Review • Previous Articles    

Research advances in the treatment of refractory Langerhans cell histiocytosis

NI Yongan, SUN Lirong()   

  1. Department of Pediatric Hematology and Oncology, the Affiliated Hospital of Qingdao University, Qingdao 266555, Shandong, China
  • Received:2024-09-12 Accepted:2024-11-22 Published:2025-10-15 Online:2025-09-29
  • Contact: SUN Lirong E-mail:sunlr@vip.sina.com

Abstract:

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm. At present, the primary therapeutic strategy is risk-stratified chemotherapy. Nevertheless, significant clinical challenges persist, including high rates of disease reactivation and a considerable number of refractory cases. Currently, no standardized treatment protocol exists for refractory LCH. Nucleoside analog-based chemotherapy remains the mainstay of therapy, although it is associated with a substantial risk of complications. While targeted therapies demonstrate rapid efficacy, disease recurrence remains a common issue. Therefore, further investigation into combination treatment strategies and optimization of therapeutic regimens is warranted. With ongoing advances in understanding the pathogenesis of LCH and the development of novel therapeutic modalities, there is optimism that the management of refractory LCH will improve significantly, ultimately leading to better patient outcomes.

Key words: Langerhans cell histiocytosis, chemotherapy, refractory, targeted therapy, child

CLC Number: 

  • R72