Journal of Clinical Pediatrics ›› 2023, Vol. 41 ›› Issue (8): 634-640.doi: 10.12372/jcp.2023.22e0820
• Continuing Medical Education • Previous Articles
WANG Yanfei, TAN Linhua
Received:
2022-06-13
Published:
2023-08-15
Online:
2023-08-10
WANG Yanfei, TAN Linhua. Research progress on the role of intestinal flora in sepsis[J].Journal of Clinical Pediatrics, 2023, 41(8): 634-640.
[1] |
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, et al. The global burden of paediatric and neonatal sepsis: a systematic review[J]. Lancet Respir Med, 2018, 6(3): 223-230.
doi: 10.1016/S2213-2600(18)30063-8 pmid: 29508706 |
[2] |
Chen P, Billiar T. Gut microbiota and multiple organ dysfunction syndrome (MODS)[J]. Adv Exp Med Biol, 2020, 1238: 195-202.
doi: 10.1007/978-981-15-2385-4_11 pmid: 32323186 |
[3] |
Brussow H. Problems with the concept of gut microbiota dysbiosis[J]. Microb Biotechnol, 2020, 13(2): 423-434.
doi: 10.1111/1751-7915.13479 pmid: 31448542 |
[4] |
Adelman MW, Woodworth MH, Langelier C, et al. The gut microbiome's role in the development, maintenance, and outcomes of sepsis[J]. Crit Care, 2020, 24(1): 278.
doi: 10.1186/s13054-020-02989-1 |
[5] |
Liu W, Cheng M, Li J, et al. Classification of the gut microbiota of patients in intensive care units during development of sepsis and septic shock[J]. Genomics Proteomics Bioinformatics, 2020, 18(6): 696-707.
doi: 10.1016/j.gpb.2020.06.011 |
[6] |
Huang M, Cai S, Su J. The Pathogenesis of Sepsis and Potential Therapeutic Targets[J]. Int J Mol Sci, 2019, 20(21) :5376.
doi: 10.3390/ijms20215376 |
[7] |
Woo V, Alenghat T. Epigenetic regulation by gut microbiota[J]. Gut Microbes, 2022, 14(1): 2022407.
doi: 10.1080/19490976.2021.2022407 |
[8] |
Ke X, You K, Pichaud M, et al. Gut bacterial metabolites modulate endoplasmic reticulum stress[J]. Genome Biol, 2021, 22(1): 292.
doi: 10.1186/s13059-021-02496-8 pmid: 34654459 |
[9] |
Riazi-Rad F, Behrouzi A, Mazaheri H, et al. Impact of gut microbiota on immune system[J]. Acta Microbiol Immunol Hung, 2021. doi: 10.1556/030.2021.01532.
doi: 10.1556/030.2021.01532 |
[10] |
Fay KT, Klingensmith NJ, Chen CW, et al. The gut microbiome alters immunophenotype and survival from sepsis[J]. FASEB J, 2019, 33(10): 11258-11269.
doi: 10.1096/fj.201802188R pmid: 31306584 |
[11] |
Chen L, Li H, Chen Y, et al. Probiotic lactobacillus rhamnosus GG reduces mortality of septic mice by modulating gut microbiota composition and metabolic profiles[J]. Nutrition, 2020, 78: 110863.
doi: 10.1016/j.nut.2020.110863 |
[12] |
Morgan RL, Preidis GA, Kashyap PC, et al. Probiotics reduce mortality and morbidity in preterm, low-birth-weight infants: a systematic review and network meta-analysis of randomized trials[J]. Gastroenterology, 2020, 159(2): 467-480.
doi: S0016-5085(20)34849-6 pmid: 32592699 |
[13] |
Suez J, Zmora N, Segal E, et al. The pros, cons, and many unknowns of probiotics[J]. Nat Med, 2019, 25(5): 716-729.
doi: 10.1038/s41591-019-0439-x pmid: 31061539 |
[14] |
Sotoudegan F, Daniali M, Hassani S, et al. Reappraisal of probiotics' safety in human[J]. Food Chem Toxicol, 2019, 129: 22-29.
doi: S0278-6915(19)30231-5 pmid: 31009735 |
[15] |
Salminen S, Collado MC, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J]. Nat Rev Gastroenterol Hepatol, 2021, 18(9): 649-667.
doi: 10.1038/s41575-021-00440-6 pmid: 33948025 |
[16] |
Mantziari A, Salminen S, Szajewska H, et al. Postbiotics against pathogens commonly involved in pediatric infectious diseases[J]. Microorganisms, 2020, 8(10): 1510.
doi: 10.3390/microorganisms8101510 |
[17] |
Wittekamp BHJ, Oostdijk EAN, Cuthbertson BH, et al. Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review[J]. Intensive Care Med, 2020, 46(2): 343-349.
doi: 10.1007/s00134-019-05883-9 pmid: 31820032 |
[18] |
Buitinck SH, Jansen R, Bosman RJ, et al. Eradication of resistant and susceptible aerobic gram-negative bacteria from the digestive tract in critically ill patients; an observational cohort study[J]. Front Microbiol, 2021, 12: 779805.
doi: 10.3389/fmicb.2021.779805 |
[19] |
Sanchez-Ramirez C, Hipola-Escalada S, Cabrera-Santana M, et al. Long-term use of selective digestive decontamination in an ICU highly endemic for bacterial resistance[J]. Critical Care, 2018, 22(1):141.
doi: 10.1186/s13054-018-2057-2 |
[20] |
Buitinck S, Jansen R, Rijkenberg S, et al. The ecological effects of selective decontamination of the digestive tract (SDD) on antimicrobial resistance: a 21-year longitudinal single-centre study[J]. Crit Care, 2019, 23(1): 208.
doi: 10.1186/s13054-019-2480-z |
[21] |
Petros A, Silvestri L, Booth R, et al. Selective decon-tamination of the digestive tract in critically ill children: systematic review and meta-analysis[J]. Pediatr Crit Care Med, 2013, 14(1): 89-97.
doi: 10.1097/PCC.0b013e3182417871 |
[22] |
Keskey R, Cone JT, DeFazio JR, et al. The use of fecal microbiota transplant in sepsis[J]. Transl Res, 2020, 226: 12-25.
doi: 10.1016/j.trsl.2020.07.002 pmid: 32649987 |
[23] |
Zhong S, Zeng J, Deng Z, et al. Fecal microbiota transplantation for refractory diarrhea in immuno-compromised diseases: a pediatric case report[J]. Ital J Pediatr, 2019, 45(1): 116.
doi: 10.1186/s13052-019-0708-9 |
[24] |
Gai X, Wang H, Li Y, et al. Fecal microbiota transplantation protects the intestinal mucosal barrier by reconstructing the gut microbiota in a murine model of sepsis[J]. Front Cell Infect Microbiol, 2021, 11: 736204.
doi: 10.3389/fcimb.2021.736204 |
[25] |
DeFilipp Z, Bloom PP, Torres Soto M, et al. Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant[J]. N Engl J Med, 2019, 381(21): 2043-2050.
doi: 10.1056/NEJMoa1910437 |
[26] |
Nicholson MR, Mitchell PD, Alexander E, et al. Efficacy of fecal microbiota transplantation for clostridium difficile infection in children[J]. Clin Gastroenterol Hepatol, 2020, 18(3): 612-619.
doi: 10.1016/j.cgh.2019.04.037 |
[27] |
Okumura T, Nozu T, Ishioh M, et al. Centrally administered butyrate improves gut barrier function, visceral sensation and septic lethality in rats[J]. J Pharmacol Sci, 2021, 146(4): 183-191.
doi: 10.1016/j.jphs.2021.04.005 pmid: 34116731 |
[28] |
Zhang H, Xu J, Wu Q, et al. Gut microbiota mediates the susceptibility of mice to sepsis-associated encephalopathy by butyric acid[J]. J Inflamm Res, 2022, 15: 2103-2119.
doi: 10.2147/JIR.S350566 pmid: 35386224 |
[29] | Weiss SL, Bittinger K, Lee JJ, et al. Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immuno-metabolic function[J]. Crit Care Explor, 2021, 3(3): e0360. |
[30] |
van der Hee B, Wells JM. Microbial regulation of host physiology by short-chain fatty acids[J]. Trends Microbiol, 2021, 29(8): 700-712.
doi: 10.1016/j.tim.2021.02.001 pmid: 33674141 |
[31] |
Fei J, Fu L, Hu B, et al. Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice[J]. Int Immunopharmacol, 2019, 66: 177-184.
doi: S1567-5769(18)31067-1 pmid: 30468885 |
[32] | Jin P, Deng S, Tian M, et al. INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/PKA/ CREB signaling axis in a rat model of sepsis[J]. Exp Neurol, 2021, 335:113504. |
[33] |
Urdaneta V, Casadesus J. Interactions between bacteria and bile salts in the gastrointestinal and hepatobiliary tracts[J]. Frontiers in Medicine, 2017, 4: 163.
doi: 10.3389/fmed.2017.00163 pmid: 29043249 |
[34] |
Chen ML, Takeda K, Sundrud MS. Emerging roles of bile acids in mucosal immunity and inflammation[J]. Mucosal Immunol, 2019, 12(4): 851-861.
doi: 10.1038/s41385-019-0162-4 pmid: 30952999 |
[35] | Lajczak-McGinley NK, Porru E, Fallon CM, et al. The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis[J]. Physiol Rep, 2020, 8(12): e14456. |
[36] | 杜转环, 马莉, 甄玲玲, 等. 5-羟色胺在脓毒症中作用机制的研究进展[J]. 中华危重病急救医学, 2019, 31(5): 662-664. |
[37] |
Gong S, Yan Z, Liu Z, et al. Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice[J]. Hepatology, 2019, 69(4): 1751-1767.
doi: 10.1002/hep.30361 pmid: 30506577 |
[38] |
Wang J, Gong S, Wang F, et al. Granisetron protects polymicrobial sepsis-induced acute lung injury in mice[J]. Biochem Biophys Res Commun, 2019, 508(4): 1004-1010.
doi: 10.1016/j.bbrc.2018.12.031 |
[39] | Juhasz L, Rutai A, Fejes R, et al. Divergent effects of the N-methyl-D-aspartate receptor antagonist kynurenic acid and the synthetic analog SZR-72 on microcirculatory and mitochondrial dysfunction in experimental sepsis[J]. Front Med (Lausanne), 2020, 7: 566-582. |
[40] |
Roager HM, Licht TR. Microbial tryptophan catabolites in health and disease[J]. Nat Commun, 2018, 9(1): 3294.
doi: 10.1038/s41467-018-05470-4 pmid: 30120222 |
[41] |
Napier BA, Andres-Terre M, Massis LM, et al. Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome[J]. Proc Natl Acad Sci U S A, 2019, 116(9): 3688-3694.
doi: 10.1073/pnas.1814273116 |
[42] | Yu C, Zhu X, Zheng C, et al. Methyl diet enhanced sepsis-induced mortality through altering gut microbiota[J]. J Inflamm Reh, 2021, 14: 3107-3121. |
[43] |
Wang H, He C, Liu Y, et al. Soluble dietary fiber protects intestinal mucosal barrier by improving intestinal flora in a murine model of sepsis[J]. Biomed Pharmacother, 2020, 129: 110343.
doi: 10.1016/j.biopha.2020.110343 pmid: 32593968 |
[44] |
Melo HM, Santos LE, Ferreira ST. Diet-derived fatty acids, brain inflammation, and mental health[J]. Front Neurosci, 2019, 13: 265.
doi: 10.3389/fnins.2019.00265 |
[45] |
Yang Q, Liang Q, Balakrishnan B, et al. Role of dietary nutrients in the modulation of gut microbiota: a narrative review[J]. Nutrients, 2020, 12(2): 381.
doi: 10.3390/nu12020381 |
[46] |
De Waele E, Malbrain M, Spapen H. Nutrition in sepsis: a bench-to-bedside review[J]. Nutrients, 2020, 12(2): 395.
doi: 10.3390/nu12020395 |
[47] |
Springer AMM, Hortencio TDR, Melro EC, et al. Hypophosphatemia in critically ill pediatric patients receiving enteral and oral nutrition[J]. JPEN J Parenter Enteral Nutr, 2021, 46(4): 842-849.
doi: 10.1002/jpen.2235 pmid: 34291462 |
[48] |
Bowlin MQ, Gray MJ. Inorganic polyphosphate in host and microbe biology[J]. Trends Microbiol, 2021, 29(11): 1013-1023.
doi: 10.1016/j.tim.2021.02.002 pmid: 33632603 |
[49] |
Nichols D, Pimentel MB, Borges FTP, et al. Sustained release of phosphates from hydrogel nanoparticles suppresses bacterial collagenase and biofilm formation in vitro[J]. Front Bioeng Biotechnol, 2019, 7: 153.
doi: 10.3389/fbioe.2019.00153 |
[50] | Liang H, Song H, Zhang X, et al. Metformin attenuated sepsis-related liver injury by modulating gut microbiota[J]. Emerg Microbes Infect, 2022: 1-34. |
[51] |
Vieira-Silva S, Falony G, Belda E, et al. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis[J]. Nature, 2020, 581(7809): 310-315.
doi: 10.1038/s41586-020-2269-x |
[52] | Liang B, Yang S-jT, Wei KK, et al. Statin use and mortality among patients hospitalized with sepsis: a retrospective cohort study within southern California, 2008-2018[J]. Crit Care Res Pract, 2022: 7127531. |
[53] |
Li Y, Zhao H, Sun G, et al. Alterations in the gut microbiome and metabolome profiles of septic rats treated with aminophylline[J]. J Transl Med, 2022, 20(1): 69.
doi: 10.1186/s12967-022-03280-3 pmid: 35115021 |
[54] | Mu S, Zhang J, Du S, et al. Gut microbiota modulation and anti-inflammatory properties of Xuanbai Chengqi decoction in septic rats[J]. J Ethnopharmacol, 2021, 267: 113534. |
[55] | Zhan L, Liu H, Zheng J, et al. Electroacupuncture at zusanli alleviates sepsis by regulating the TLR4-MyD88-NF-Kappa B pathway and diversity of intestinal flora[J]. Evid Based Complement Alternat Med, 2022: 6706622. |
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