临床儿科杂志 ›› 2019, Vol. 37 ›› Issue (6): 423-.doi: 10.3969/j.issn.1000-3606.2019.06.006

• 呼吸系统疾病专栏 • 上一篇    下一篇

肺炎支原体肺炎闭塞性支气管炎1 例报告并文献复习

易茜1,2,吴毅1,2,李媛媛1,2,田小银1,张光莉1,谢晓虹1,罗征秀1   

  1. 1.重庆医科大学附属儿童医院呼吸科,2.儿童发育疾病研究教育部重点实验室 儿童发育重大疾病 国家国际科技合作基地 儿科学重庆市重点实验室(重庆 400014)
  • 出版日期:2019-06-15 发布日期:2019-06-10
  • 通讯作者: 罗征秀 电子信箱:luozhengxiu816@163.com
  • 基金资助:
    国家临床重点专科建设项目资助(No.2011-873)

Bronchitis obliterans due to Mycoplasma Pneumoniae pneumonia in children: a case report and literature review

YI Qian1,2, WU Yi1,2, LI Yuanyuan1,2, TIAN Xiaoyin1, ZHANG Guangli1, XIE Xiaohong1, LUO Zhengxiu1   

  1. 1.Department of Respiratory, Children's Hospital of Chongqing Medical University; 2.Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base for Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
  • Online:2019-06-15 Published:2019-06-10

摘要: 目的 探讨肺炎支原体肺炎(MPP)闭塞性支气管炎的临床特点。方法 回顾分析1例MPP闭塞性支气管炎 患儿的临床资料,并复习相关文献,总结MPP继发闭塞性支气管炎的临床、影像学及支气管镜下特点。结果 4岁男童, 以重症MPP 1月余后气促、活动不耐受为主要临床表现,体检发现左侧胸廓塌陷,左肺呼吸音低。肺部影像学示纵隔心影 左移,左肺下叶不张,左肺下叶各段支气管扩张,右肺马赛克灌注征。支气管镜下见左上舌段、左下前外基底段亚支闭塞。 经2次支气管镜球囊扩张、支气管肺泡灌洗及布地奈德雾化吸入等治疗,半年后胸部CT示部分肺复张。检索到19篇文献, 72例患儿,其中有MPP病史49例。在MPP后1~2个月内逐渐出现气促、喘息、活动不耐受等表现,体格检查多可在患侧 肺闻及支气管呼吸音,影像学则以持续性肺实变或肺不张为特点,通过阿奇霉素序贯联合糖皮质激素及支气管镜等治疗, 随访17例, 8例有所改善。结论 重症MPP后出现气促、喘息、活动耐量下降等表现,影像检查提示单侧肺不张,应警惕闭 塞性支气管炎,早期支气管镜诊治可能对改善预后有一定积极作用。

关键词: 肺炎支原体肺炎; 闭塞性支气管炎; 支气管镜; 儿童

Abstract: Objective To explore the clinical characteristics of bronchitis obliterans due to Mycoplasma pneumoniae pneumonia (MPP). Methods The clinical data of bronchitis obliterans due to MPP in a child was retrospectively analyzed, and the related literature was reviewed. The clinical, imaging, and bronchoscopic features of bronchitis obliterans secondary to MPP were summarized. Results A 4-year-old boy presented with shortness of breath and activity intolerance after 1 month of severe MPP. Physical examination revealed left thoracic collapse and low breathing sound in left lung. Pulmonary imaging showed a shift of the mediastinal heart shadow to the left, atelectasis and bronchiectasis in left lower lobe and mosaic perfusion in right lung. Bronchoscopy showed sub-branch occlusion of left upper tongue lobe segment and left lower anterior outer basal segment. After bronchoscopic balloon dilatation twice, bronchoalveolar lavage and budesonide atomization inhalation, the chest CT showed partial pulmonary reexpansion six months later. From the search, nineteen papers were retrieved including a total of 72 cases, 49 of which had a history of MPP. The children gradually presented shortness of breath, wheezing, activity intolerance and other manifestations within 1-2 months after MPP. Bronchial breath sound can be heard in the affected side. Imaging was characterized by persistent pulmonary consolidation or atelectasis. After sequential treatment with azithromycin combined with glucocorticoids and bronchoscopy, 8 of the 17 patients who received follow-up were improved. Conclusion Secondary to MPP, when a patient manifested shortness of breath, wheezing and impaired activity tolerance and imaging examination suggested unilateral atelectasis, clinicians should be alerted to the occurrence of bronchitis obliterans. Early diagnosis and treatment by the use of bronchoscopy may play a positive role in improving prognosis.

Key words: Mycoplasma pneumoniae pneumonia; bronchitis obliterans; bronchoscopy; child