妊娠期合并系统性红斑狼疮对子代影响及作用机制

doi:10.12372/jcp.2022.21e1174

摘要/Abstract

摘要：

系统性红斑狼疮(SLE)是一种严重的多系统自身免疫性疾病,绝大多数患者为育龄期女性。妊娠期合并SLE对胎儿、新生儿以及子代远期都会产生影响, 包括死胎、流产、胎盘早剥、宫内发育迟缓及早产发生率升高等。少数还可引起新生儿狼疮(NL),甚至对后代神经认知等方面产生影响。另外,SLE患者孕前及孕期需要口服药物控制疾病,其中多数会对子代产生影响。因此,建议SLE患者孕前和孕期严密监测,优化治疗,对其后代进行整体评估,以降低对子代的不利影响。文章利用文献调查分析妊娠期合并SLE对子代影响及其作用机制,同时阐述妊娠期使用SLE药物对后代影响。

关键词: 系统性红斑狼疮, 妊娠期, 子代

Abstract:

Systemic lupus erythematosus (SLE) is a serious multi-system autoimmune disease, and the vast majority of patients are women of childbearing age. The fetus, newborns and offspring in the long term will be affected by the SLE during pregnancy, including stillbirth, miscarriage, placental abruption, intrauterine growth retardation and the increase in preterm birth incidence. A few cases can also cause neonatal lupus (NL), and even have negative effect on the neurocognition of offspring. Moreover, women with SLE need oral medications before and during pregnancy to control the disease, which will affect offspring in most cases. Therefore, it is recommended that patients with SLE are monitored closely before and during pregnancy. Meanwhile, the optimized treatment and overall evaluation of their offspring will be applied to reduce the adverse effects on the offspring. The effect of SLE during pregnancy on offspring and its mechanism is summarized in this paper by literature review. The effects of drugs for SLE during pregnancy on offspring were also discussed.

Key words: systemic lupus erythematosus, pregnancy, offspring

宋雅婷综述, 孙建华审校. 妊娠期合并系统性红斑狼疮对子代影响及作用机制[J]. 临床儿科杂志, 2022, 40(7): 550-554.

Reviewer: SONG Yating, Reviser: SUN Jianhua. Effects of systemic lupus erythematosus during pregnancy on offspring and its mechanism[J]. Journal of Clinical Pediatrics, 2022, 40(7): 550-554.

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