以下肢动脉血栓为首发表现的儿童系统性红斑狼疮合并抗磷脂综合征2例报告

doi:10.12372/jcp.2026.25e1528

临床儿科杂志 ›› 2026, Vol. 44 ›› Issue (6): 579-583.doi: 10.12372/jcp.2026.25e1528

以下肢动脉血栓为首发表现的儿童系统性红斑狼疮合并抗磷脂综合征2例报告

储卫红¹, 徐莉燕¹, 彭韶¹, 赖建铭²()

¹ 郑州大学第一附属医院儿科（河南郑州 450000）
² 首都医科大学附属首都儿童医学中心风湿免疫科（北京 100020）

收稿日期:2025-12-05 修回日期:2026-03-02 录用日期:2026-04-21 出版日期:2026-06-15 发布日期:2026-06-04
通讯作者: 赖建铭 E-mail:laijm99@sina.com
作者简介:第一联系人：作者贡献（Authors’ Contributions）
储卫红查阅文献、撰写论文；徐莉燕临床资料收集、整理；彭韶指导资料收集及论文撰写；赖建铭临床资料收集整理、指导论文撰写。

Lower extremity arterial thrombosis as first clinical manifestation in children's systemic lupus erythematosus complicated with antiphospholipid syndrome: a two-case report

CHU Weihong¹, XU Liyan¹, PENG Shao¹, LAI Jianming²()

¹ Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China
² Department of Rheumatology and Immunology, Capital Center for Children's Health Capital Medical University, Beijing 100020, China

Received:2025-12-05 Revised:2026-03-02 Accepted:2026-04-21 Published:2026-06-15 Online:2026-06-04
Contact: LAI Jianming E-mail:laijm99@sina.com

摘要/Abstract

摘要：

总结儿童系统性红斑狼疮合并抗磷脂综合征致下肢动脉血栓临床特点、治疗及预后，为临床医师提供诊治参考经验。收集系统性红斑狼疮合并抗磷脂综合征致下肢动脉血栓病例2例，比较分析其临床特点、治疗方案及预后的差异。患儿1给予糖皮质激素+环磷酰胺+贝利尤单抗+丙种球蛋白+羟氯喹+抗凝药物等治疗，最终仍出现坏疽，趾骨坏死脱落。随诊4年，血栓未再复发。患儿2给予糖皮质激素+利妥昔单抗+羟氯喹+抗凝药物+球囊扩张术+置管溶栓血栓抽吸术等治疗，随诊9个月，预后良好。儿童系统性红斑狼疮合并抗磷脂综合征可出现下肢动脉血栓，存在严重不良预后风险，应尽早诊断，积极治疗。

关键词: 下肢动脉血栓, 系统性红斑狼疮, 抗磷脂综合征, 儿童

Abstract:

To summarize clinical characteristics, treatment and prognosis of lower extremity arterial thrombosis caused by systemic lupus erythematosus (SLE) complicated with antiphospholipid syndrome (APS) in children, and to provide diagnostic and therapeutic experience for clinicians. Two cases of lower extremity arterial thrombosis caused by SLE complicated with APS were collected.The differences in clinical characteristics, treatment plans and prognosis were compared and analyzed between two cases. Patient 1 was treated with glucocorticoids, cyclophosphamide, belimumab, intravenous immunoglobulins, hydroxychloroquine and anticoagulation drug. However, gangrene still occurred, resulting in necrosis and eventual auto-amputation of toe bones. During a follow-up of 4 years, no thrombotic events recurred. Patient 2 was treated with glucocorticoids, rituximab, hydroxychloroquine, anticoagulation drug, balloon dilation, catheter-directed thrombolysis and thrombus aspiration. The patient had a good prognosis after 9 months of follow-up. Children with SLE complicated by APS may develop lower extremity arterial thrombosis, which carries a risk of serious adverse outcomes. Early diagnosis and active treatment are crucial.

Key words: lower extremity arterial thrombosis, systemic lupus erythematosus, antiphospholipid syndrome, child

中图分类号:

储卫红, 徐莉燕, 彭韶, 赖建铭. 以下肢动脉血栓为首发表现的儿童系统性红斑狼疮合并抗磷脂综合征2例报告[J]. 临床儿科杂志, 2026, 44(6): 579-583.

CHU Weihong, XU Liyan, PENG Shao, LAI Jianming. Lower extremity arterial thrombosis as first clinical manifestation in children's systemic lupus erythematosus complicated with antiphospholipid syndrome: a two-case report[J]. Journal of Clinical Pediatrics, 2026, 44(6): 579-583.

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参考文献 15

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以下肢动脉血栓为首发表现的儿童系统性红斑狼疮合并抗磷脂综合征2例报告

Lower extremity arterial thrombosis as first clinical manifestation in children's systemic lupus erythematosus complicated with antiphospholipid syndrome: a two-case report

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