关键词: 短肠综合征, 导管相关性血流感染, 肠外营养, 儿童

Abstract: Objective To explore the incidence and risk factors of catheter-related bloodstream infection (CRBSI) in children with short bowel syndrome (SBS). Methods The clinical data of SBS in 19 children admitted from August 2015 to December 2019 was retrospectively analyzed and the incidence of CRBSI and related risk factors were evaluated. Results Among the 19 children with SBS, the catheterization was performed 57 times, and the total catheterization days were 1907 days. CRBSI occurred 11 times in 6 children, with an incidence of 5 . 8 times per 1000 catheter days. The common manifestations of the SBS children with CRBSI were fever ( 6 / 11 , 54 . 5 %), lethargy ( 5 / 11 , 45 . 4 %), stagnation of weight ( 7 / 11 , 63 . 6 %) and increment of enterostomy fluid ( 7 / 11 , 63 . 6 %). Compared with the non-CRBSI group, the proportion of ileocecal valve loss and the duration of parenteral nutrition ≥ 120 days in the CRBSI group were higher, and the differences were statistically significant (P< 0 . 05 ). A total of 11 positive results were obtained in blood culture of children with SBS when CRBSI occurred, and the most common pathogenic microorganism was Klebsiella pneumoniae ( 6 / 11 , 54.55%). Conclusions The occurrence of CRBSI may be related to ileocecal valve loss and long duration of parenteral nutrition.

Key words: short bowel syndrome, catheter-related bloodstream infections, parenteral nutrition, child