移植治疗在儿童与青少年1型糖尿病治疗中的应用进展

doi:10.12372/jcp.2022.22e0253

临床儿科杂志 ›› 2022, Vol. 40 ›› Issue (5): 334-338.doi: 10.12372/jcp.2022.22e0253

移植治疗在儿童与青少年1型糖尿病治疗中的应用进展

陈瑶, 王秀敏()

上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科(上海 200127)

收稿日期:2022-02-28 出版日期:2022-05-15 发布日期:2022-05-13
通讯作者: 王秀敏 E-mail:wangxiumin@scmc.com.cn
作者简介:陈瑶,博士ORCID：0000-0002-5811-7880,青年编委,（1987—）,上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科主治医师。儿科学博士,上海交通大学优秀毕业生,上海市“医苑新星”青年医学人才,《临床儿科杂志》青年编委。擅长儿童内分泌常见疾病如儿童性早熟、矮小症、肥胖症、糖尿病、甲状腺功能异常等疾病诊治。在科普宣教方面有丰富经验,获2018“唯爱伴我行,上海市住院医师科普月月讲”大赛二等奖、2020年医学专科科普能力大赛决赛“儿童生长发育相关主题”三等奖。主持国家自然科学基金项目1项、上海交通大学“交大之星”项目1项,参与多项国家自然科学基金以及市级、院级课题研究。目前已发表中文核心期刊论文近20余篇,SCI论文10余篇（其中第一作者发表2篇Q1、共同第一作者1篇 Q4）。
基金资助:
国家自然科学基金项目(82170910);国家自然科学基金项目(81903341)

Advances in transplantation therapy in the treatment of type 1 diabetes in children and adolescents

CHEN Yao, WANG Xiumin()

Department of Endocrine Genetic Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Received:2022-02-28 Online:2022-05-15 Published:2022-05-13
Contact: WANG Xiumin E-mail:wangxiumin@scmc.com.cn

摘要/Abstract

摘要：

儿童与青少年1型糖尿病的患病率在近数十余年来呈现明显的上升趋势,传统的药物治疗方法可有效地改善血糖,但无法达到根治的目的。移植治疗作为一种可能达到根治目标的治疗方案受到越来越多的关注,主要包括胰岛移植、干细胞移植以及胰腺移植。移植后伴随的排异反应、胰岛细胞炎症及凋亡反应等仍是目前限制移植治疗在1型糖尿病治疗中应用的重大瓶颈,未来有望通过一氧化碳暴露或调节性T细胞治疗等相关方法得到一定突破。目前移植治疗在1型糖尿病中的研究主要集中在动物研究或成人临床试验中,关于儿童与青少年1型糖尿病移植治疗的研究报道相对较少。粪菌移植未来有望成为1型糖尿病辅助治疗的方法,达到辅助改善胰岛功能的目的。

关键词: 移植, 儿童, 青少年, 1型糖尿病

Abstract:

Prevalence of type 1 diabetes in children and adolescents rises in decades of years. Medication could keep the serum level of glucose in a reasonable range rather than cure the disease. Transplantation, mainly islet transplantation, stem cell transplantation and pancreas transplantation, has attracted more attention for the possibility of curing type 1 diabetes. Rejection, islet inflammation and apoptosis hinder a successful transplantation, which may be relieved by carbon monoxide or regulatory T cell therapies. Most of studies about transplantation treatment for type 1 diabetes were on animals or adults, with few on children and adolescents. Furthermore, fecal microbiota transplantation could halt progression of human new-onset type 1 diabetes, which could be an adjuvant therapy in future days.

Key words: transplantation, child, adolescent, type 1 diabetes

陈瑶, 王秀敏. 移植治疗在儿童与青少年1型糖尿病治疗中的应用进展[J]. 临床儿科杂志, 2022, 40(5): 334-338.

CHEN Yao, WANG Xiumin. Advances in transplantation therapy in the treatment of type 1 diabetes in children and adolescents[J]. Journal of Clinical Pediatrics, 2022, 40(5): 334-338.

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移植治疗在儿童与青少年1型糖尿病治疗中的应用进展

Advances in transplantation therapy in the treatment of type 1 diabetes in children and adolescents

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