肠道菌群及其代谢产物在新生儿坏死性小肠结肠炎中研究现状与潜在应用思考

doi:10.12372/jcp.2022.22e0301

临床儿科杂志 ›› 2022, Vol. 40 ›› Issue (9): 654-660.doi: 10.12372/jcp.2022.22e0301

肠道菌群及其代谢产物在新生儿坏死性小肠结肠炎中研究现状与潜在应用思考

李禄全, 刘晓晨

重庆医科大学附属儿童医院新生儿科儿科学重庆市重点实验室国家儿童健康与疾病临床医学研究中心儿童发育重大疾病国家国际科技合作基地儿童发育疾病研究教育部重点实验室（重庆 400014）

收稿日期:2022-03-07 出版日期:2022-09-15 发布日期:2022-08-26
作者简介:李禄全,儿科学博士,重庆医科大学附属儿童医院新生儿科副主任,主任医师/教授,硕士研究生导师,美国佛罗里达大学访问学者。兼任重庆市妇幼卫生学会儿童健康专业委员会生命支持学组副组长,重庆市新生儿围产医学专委会副主任委员,重庆市围产医学专委会第六届委员会新生儿窒息复苏学组组长,《Frontier in Pediatrics》海外审稿编辑,《临床儿科杂志》《中国当代儿科杂志》青年编委,《BMC Pediatrics》《重庆医科大学学报》《儿科药学杂志》特邀审稿人。发表学术论文70余篇,参编专著及本科教材4部,获得重庆市政府三等奖、重庆市卫生局二等奖各一次。
基金资助:
重庆市科卫联合医学科研基金(2022MSXM039);重庆市自然科学基金(cstc2021jcyj-msxmX0063)

Research status and potential application of intestinal microbiota and its metabolites in neonatal necrotizing enterocolitis

LI Luquan, LIU Xiaochen

Department of Neonatology, Children’s Hospital of Chongqing Medical University, Key Laboratory of Pediatrics in Chongqing, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China

Received:2022-03-07 Online:2022-09-15 Published:2022-08-26

摘要/Abstract

摘要：

肠道菌群及其代谢产物早期预测坏死性小肠结肠炎（NEC）是近年来研究的热点。近年研究发现NEC患儿肠道菌群不仅生物多样性较低,且菌群构成比例与健康新生儿明显不同。NEC患儿氨基酸、脂代谢以及与此相关的代谢酶类也存在异常。肠道菌群及其代谢产物在预测NEC发病及病情进展等方面有一定价值,但目前只能作为科学研究探讨的依据,临床运用尚需要高质量、多中心、大样本量临床研究予以验证。

关键词: 坏死性小肠结肠炎, 肠道菌群, 代谢产物, 标志物

Abstract:

The early prediction of necrotizing enterocolitis (NEC) by intestinal microbiota and its metabolites has been a hot research topic in recent years. Recent studies have found that infants with necrotizing enterocolitis (NEC) not only have low biodiversity of the intestinal microbiota, but also the composition proportion of microbiota is significantly different from that of healthy newborns. There are also abnormalities in amino acid, lipid metabolism and related metabolic enzymes in infants with NEC. Intestinal microbiota and its metabolites have certain value in predicting the onset and progression of NEC, but they can only be used as the basis for scientific research. High-quality, multi-center, and large-scale clinical studies are needed for clinical application in the future.

Key words: necrotizing enterocolitis, intestinal microbiota, metabolite, biomarker

李禄全, 刘晓晨. 肠道菌群及其代谢产物在新生儿坏死性小肠结肠炎中研究现状与潜在应用思考[J]. 临床儿科杂志, 2022, 40(9): 654-660.

LI Luquan, LIU Xiaochen. Research status and potential application of intestinal microbiota and its metabolites in neonatal necrotizing enterocolitis[J]. Journal of Clinical Pediatrics, 2022, 40(9): 654-660.

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肠道菌群及其代谢产物在新生儿坏死性小肠结肠炎中研究现状与潜在应用思考

Research status and potential application of intestinal microbiota and its metabolites in neonatal necrotizing enterocolitis

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