肠道菌群在脓毒症中的作用和研究进展

doi:10.12372/jcp.2023.22e0820

摘要/Abstract

摘要：

脓毒症是宿主对感染的反应失调所致的危及生命的器官功能障碍，影响儿童健康。肠道菌群在宿主的代谢和免疫方面发挥着重要的调节作用，与多种疾病相关。研究表明，脓毒症及临床诊疗可导致患儿肠道菌群失调，从而进一步影响疾病的预后；而正常的肠道菌群可减少儿童对脓毒症的易感性，提高脓毒症的存活率，改善脏器功能的损害。文章就肠道菌群与脓毒症的相关性研究作一介绍，以期有助于儿童脓毒症的预防及治疗。

关键词: 脓毒症, 肠道菌群, 代谢, 儿童

Abstract:

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection which affects children's health. The intestinal flora play an important regulatory role in host metabolism and immunity and are associated with a variety of diseases. Studies have shown that sepsis and clinical treatments can lead to intestinal flora imbalance in children, which further affects the prognosis of the disease; while healthy intestinal flora can reduce the susceptibility of children to sepsis and improve the survival of sepsis, and ameliorate the damage to the function of organs. This article reviews the related research on intestinal flora and sepsis, in order to contribute to the prevention and treatment of sepsis in children.

Key words: sepsis, intestinal flora, metabolism, child

王燕飞, 谈林华. 肠道菌群在脓毒症中的作用和研究进展[J]. 临床儿科杂志, 2023, 41(8): 634-640.

WANG Yanfei, TAN Linhua. Research progress on the role of intestinal flora in sepsis[J]. Journal of Clinical Pediatrics, 2023, 41(8): 634-640.

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