新生儿坏死性小肠结肠炎研究进展与展望

doi:10.12372/jcp.2022.22e1060

摘要/Abstract

摘要：

坏死性小肠结肠炎（NEC）的早期识别和严重程度判断较为困难,临床常使用Bell分期作为其诊断及分期标准。随着分子医学和新生儿医学水平的提高,NEC的预防、治疗和管理策略都有了新的进展,但其发病率和病死率仍居高不下。近年来,组学与临床数据结合寻找早期预测NEC的相关生物标志物、母乳喂养及维持肠道菌群稳态对NEC的预防、干细胞和外泌体相关治疗的探索,都为NEC诊治带来了新方向,有望降低NEC发生率和病死率,改善患儿远期预后。

关键词: 坏死性小肠结肠炎, 组学, 预防, 干细胞, 外泌体

Abstract:

It is difficult to early identify necrotizing enterocolitis (NEC) and its severity of illness. The Bell staging criteria is widely utilized to diagnose and evaluate the severity of NEC in clinical practice. Thanks to much advancement that have been achieved in molecular biology and neonatology, the preventive and therapeutic strategies for NEC are significantly improved. However, the morbidity and mortality of NEC are still unchanged. In recent years, the combination of omics and clinical data to find relevant biomarkers for early prediction of NEC, the prevention of NEC by breastfeeding and maintenance of gut microbiota homeostasis, and the exploration of stem cell and exosome related treatment have all brought new directions for the diagnosis and treatment of NEC. These means above will bring some new hopes to reduce the morbidity and mortality of NEC and improve its long-term outcomes.

Key words: necrotizing enterocolitis, omics, prevention, stem cell, exosome

朱雪萍, 钱继红. 新生儿坏死性小肠结肠炎研究进展与展望[J]. 临床儿科杂志, 2022, 40(9): 641-646.

ZHU Xueping, QIAN Jihong. Advances in the diagnosis and treatment of neonatal necrotizing enterocolitis[J]. Journal of Clinical Pediatrics, 2022, 40(9): 641-646.

图/表 1

参考文献 39

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