脂质代谢在哮喘中作用机制的研究进展

doi:10.12372/jcp.2024.23e0201

摘要/Abstract

摘要：

哮喘是最常见的慢性呼吸系统疾病之一，累及全年龄段,其患病率与社会医疗费用逐年升高。近年来大量研究证实，脂质分子作为调节多种细胞生物过程强有力的信号分子，通过对哮喘患者气道不同细胞的调节，影响疾病的发生发展。因此，本文从近年来不断发展的脂质组学与哮喘的研究出发，总结哮喘中潜在的代谢生物标志物，探讨脂质代谢在哮喘发病过程对不同细胞发挥的作用机制，为哮喘的个性化治疗提供思路。

关键词: 哮喘, 脂质代谢, 脂质组学, 脂肪酸, 免疫细胞

Abstract:

Asthma is one of the most common chronic respiratory diseases, affecting all age group. Its prevalence and social healthcare costs are increasing every year. The results of numerous studies in recent years have conclusively demonstrated the role of lipid molecules as powerful signaling molecules that regulate a variety of cellular biological processes. By regulating different cells in the airways of asthma patients, they influence the occurrence and development of the disease. Therefore, this article summarizes the potential metabolic biomarkers in asthma, and explores the mechanisms of lipid metabolism in asthma pathogenesis on different cells to provide ideas for personalized asthma treatment from the lipidomics and asthma studies that have been developed in recent years.

Key words: asthma, lipid metabolism, lipidomics, fatty acids, immune cell

陈少甜, 杨男. 脂质代谢在哮喘中作用机制的研究进展[J]. 临床儿科杂志, 2024, 42(5): 461-466.

CHEN Shaotian, YANG Nan. Research progress on mechanism of lipid metabolism in asthma[J]. Journal of Clinical Pediatrics, 2024, 42(5): 461-466.

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