肠道菌群在儿童过敏性疾病中的研究进展

doi:10.12372/jcp.2024.23e1054

摘要/Abstract

摘要：

过敏性疾病持续对广大儿童群体健康构成严峻威胁与重大挑战。因此尽早进行针对性干预，防止疾病进展是迫切需要解决的问题。人体肠道微生物区系是在3岁时建立的，分娩方式的不同和3岁前抗生素使用等因素引起的肠道菌群失衡与过敏性疾病发病率密切相关。新一代测序方法的发展揭示了过敏性疾病患者中存在的生物失调，这增加了人们对生物失调与过敏性疾病发展之间关系的关注。肠道菌群的失调与儿童未来发展为过敏性疾病的高风险相关并且肠道菌群的变化可能作为过敏性疾病的治疗靶点。

关键词: 肠道菌群, 过敏性疾病, 哮喘, 食物过敏, 儿童

Abstract:

In recent years, allergic diseases continue to pose a major threat and challenge to the health of a wide range of children, thereby calling for urgent intervention to prevent the progression of the disease. The human gut microbiota is established by the age of 3 years. The imbalance in the gut microbiota occurs due to factors, such as cesarean delivery and antibiotic use before the age of 3 years, is strongly associated with a higher risk of future onset of allergic diseases. Recent advancements in next-generation sequencing methods have revealed the presence of dysbiosis in patients with allergic diseases, which increases attention on the relationship between dysbiosis and the development of allergic diseases. A large number of researchers have conducted in-depth research on the correlation between gut microbiota and allergic diseases, and the research results have revealed that the imbalance of gut microbiota is associated with the high risk of children developing allergic diseases in the future, and the changes in gut microbiota may be used as therapeutic targets for allergic diseases. Therefore, the purpose of this paper is mainly to review the latest research progress of gut microbiota in children with allergic diseases, and try to further promote the treatment and prevention of clinical diseases by comparing the gut microbiota of children with allergic diseases and normal children.

Key words: gut microbiota, allergic diseases, asthma, food allergy, child

邓梦路, 张婕, 盛文彬. 肠道菌群在儿童过敏性疾病中的研究进展[J]. 临床儿科杂志, 2024, 42(8): 741-746.

DENG Menglu, ZHANG Jie, SHENG Wenbin. Research progress of gut microbiota in allergic diseases in children[J]. Journal of Clinical Pediatrics, 2024, 42(8): 741-746.

参考文献 38

[1]	Zhang P. The role of diet and nutrition in allergic diseases[J]. Nutrients, 2023, 15(17): 3683.
[2]	中华儿科杂志编辑委员会, 中华医学会儿科学分会. 儿童过敏性疾病诊断及治疗专家共识[J]. 中华儿科杂志, 2019, 57(3): 164-171.
[3]	Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity[J]. Nat Rev Immunol, 2016, 16(6): 341-352. doi: 10.1038/nri.2016.42 pmid: 27231050
[4]	Akagawa S, Kaneko K. Gut microbiota and allergic diseases in children[J]. Allergol Int, 2022, 71(3): 301-309.
[5]	Pascal M, Perez-Gordo M, Caballero T, et al. Microbiome and allergic diseases[J]. Front Immunol, 2018, 9: 1584. doi: 10.3389/fimmu.2018.01584 pmid: 30065721
[6]	Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body[J]. PLoS Biol, 2016, 14(8): e1002533.
[7]	Turnbaugh PJ, Ley RE, Hamady M, et al. The human microbiome project[J]. Nature, 2007, 449(7164): 804-810.
[8]	Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, et al. The maternal microbiota drives early postnatal innate immune development[J]. Science, 2016, 351(6279): 1296-1302. doi: 10.1126/science.aad2571 pmid: 26989247
[9]	王梅, 曾湘晖, 袁丽薇, 等. 母体微生物群对子代菌群建立及健康的影响[J]. 实用妇产科杂志, 2023, 39(8): 595-598.
[10]	Odamaki T, Kato K, Sugahara H, et al. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study[J]. BMC Microbiol, 2016, 16: 90. doi: 10.1186/s12866-016-0708-5 pmid: 27220822
[11]	Yatsunenko T, Rey FE, Manary MJ, et al. Human gut microbiome viewed across age and geography[J]. Nature, 2012, 486(7402): 222-227.
[12]	Donald K, Finlay BB. Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease[J]. Nat Rev Immunol, 2023, 23(11): 735-748. doi: 10.1038/s41577-023-00874-w pmid: 37138015
[13]	Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease[J]. Nat Rev Immunol, 2013, 13(5): 321-335. doi: 10.1038/nri3430 pmid: 23618829
[14]	Akagawa S, Tsuji S, Onuma C, et al. Effect of delivery mode and nutrition on gut microbiota in neonates[J]. Ann Nutr Metab, 2019, 74(2): 132-139. doi: 10.1159/000496427 pmid: 30716730
[15]	Shao Y, Forster SC, Tsaliki E, et al. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth[J]. Nature, 2019, 574(7776): 117-121.
[16]	Fouhy F, Watkins C, Hill CJ, et al. Perinatal factors affect the gut microbiota up to four years after birth[J]. Nat Commun, 2019, 10(1): 1517.
[17]	Salminen S, Gibson GR, McCartney AL, et al. Influence of mode of delivery on gut microbiota composition in seven year old children[J]. Gut, 2004, 53(9): 1388-1389. doi: 10.1136/gut.2004.041640 pmid: 15306608
[18]	Mitselou N, Hallberg J, Stephansson O, et al. Cesarean delivery, preterm birth, and risk of food allergy: Nationwide Swedish cohort study of more than 1 million children[J]. J Allergy Clin Immunol, 2018, 142(5): 1510-1514. doi: S0091-6749(18)31070-4 pmid: 30213656
[19]	Akagawa Y, Kimata T, Akagawa S, et al. Impact of long-term low dose antibiotic prophylaxis on gut microbiota in children[J]. J Urol, 2020, 204(6): 1320-1325.
[20]	Yamamoto-Hanada K, Yang L, Narita M, et al. Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5[J]. Ann Allergy Asthma Immunol, 2017, 119(1): 54-58.
[21]	Mitre E, Susi A, Kropp LE, et al. Association between use of acid-suppressive medications and antibiotics during infancy and allergic diseases in early childhood[J]. JAMA Pediatr, 2018, 172(6): e180315.
[22]	Hoskinson C, Dai DLY, Del Bel KL, et al. Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease[J]. Nat Commun, 2023, 14(1): 4785.
[23]	Savage JH, Lee-Sarwar KA, Sordillo J, et al. A prospective microbiome-wide association study of food sensitization and food allergy in early childhood[J]. Allergy, 2018, 73(1): 145-152. doi: 10.1111/all.13232 pmid: 28632934
[24]	Chen CC, Chen KJ, Kong MS, et al. Alterations in the gut microbiotas of children with food sensitization in early life[J]. Pediatr Allergy Immunol, 2016, 27(3): 254-262.
[25]	Yu Z, Yue L, Yang Z, et al. Impairment of intestinal barrier associated with the alternation of intestinal flora and its metabolites in cow's milk protein allergy[J]. Microb Pathog, 2023, 183: 106329.
[26]	Notarbartolo V, Carta M, Accomando S, et al. The first 1000 days of life: how changes in the microbiota can influence food allergy onset in children[J]. Nutrients, 2023, 15(18): 4014.
[27]	Gao K, Chen L, Chen C, et al. Leuconostoc mesenteroides WHH1141 ameliorates ovalbumin-induced food allergy in mice[J]. J Food Sci, 2023, 88(10): 4289-4304. doi: 10.1111/1750-3841.16760 pmid: 37680119
[28]	Pessôa R, Clissa PB, Sanabani SS. The Interaction between the host genome, epigenome, and the gut-skin axis microbiome in atopic dermatitis[J]. Int J Mol Sci, 2023, 24(18): 14322.
[29]	Kim JH, Lee SH, Kang MJ, et al. Host-microbial interactions between PTGR2 and Bifidobacterium in the early life gut of atopic dermatitis children[J]. Pediatr Allergy Immunol, 2022, 33(2): e13724.d
[30]	Anania C, Brindisi G, Martinelli I, et al. Probiotics function in preventing atopic dermatitis in children[J]. Int J Mol Sci, 2022, 23(10): 5409.
[31]	Zhang P, Zhou X, Tan H, et al. Microbial signature of intestine in children with allergic rhinitis[J]. Front Microbiol, 2023, 14: 1208816.
[32]	Wan J, Song J, Lv Q, et al. Alterations in the gut microbiome of young children with airway allergic disease revealed by next-generation sequencing[J]. J Asthma Allergy, 2023, 16: 961-972. doi: 10.2147/JAA.S422537 pmid: 37700874
[33]	Liu P, Hu T, Kang C, et al. Research advances in the treatment of allergic rhinitis by probiotics[J]. J Asthma Allergy, 2022, 15: 1413-1428. doi: 10.2147/JAA.S382978 pmid: 36238950
[34]	Du B, Fu Y, Han Y, et al. The lung-gut crosstalk in respiratory and inflammatory bowel disease[J]. Front Cell Infect Microbiol, 2023, 13: 1218565.
[35]	Venkatesan P. Gut microbiota and the risk of childhood asthma[J]. Lancet Respir Med, 2015, 3(11): 843.
[36]	Johnson CC, Ownby DR. The infant gut bacterial microbiota and risk of pediatric asthma and allergic diseases[J]. Transl Res, 2017, 179: 60-70. doi: S1931-5244(16)30103-7 pmid: 27469270
[37]	Mahdavinia M, Fyolek JP, Jiang J, et al. Gut microbiome is associated with asthma and race in children with food allergy[J]. J Allergy Clin Immunol, 2023, 152(6): 1541-1549. doi: 10.1016/j.jaci.2023.07.024 pmid: 37714436
[38]	Demirci M, Tokman HB, Uysal HK, et al. Reduced Akkermansia muciniphila and faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma[J]. Allergol Immunopathol (Madr), 2019, 47(4): 365-371.