上海市市郊两区16岁以下儿童流感疫苗接种情况及影响因素分析

doi:10.12372/jcp.2026.25e1162

Abstract

Abstract:

Objective To understand the influenza vaccination situation of children under 16 years old in Shanghai and parents' awareness of influenza and influenza vaccines, analyze the influencing factors of influenza vaccination, and provide a reference basis for improving the influenza vaccination rate and preventing the prevalence of influenza among children. Methods A total of 527 subjects from Yangpu District and Baoshan District in Shanghai were selected from September 2024 to February 2025, by convenience sampling for a questionnaire survey. The questionnaire included an influenza vaccination status survey and a self-made survey on knowledge about influenza and the influenza vaccine. Multivariate logistic regression was used to analyze factors associated with childhood influenza vaccination. Results A total of 527 questionnaires were distributed, 525 were collected, and 506 were valid, yielding an effective rate of 96.4%. Among the 506 children, 244 (48.2%) were boys and 262 (51.8%) were girls, with a median age of 8 (5-11) years. A total of 287 children (56.7%) had been vaccinated against influenza, of whom 133 had received at least one dose, 76 were vaccinated only during the flu season, and 78 were vaccinated annually; 219 children (43.3%) had never been vaccinated. The main reason why parents are willing to have their children vaccinated against the flu is to prevent flu infection, while concerns about vaccine safety were the main reasons parents were unwilling to vaccinate their children or reluctant to vaccinate again. Multivariate logistic regression showed that history of preterm birth (OR=0.38, 95% CI: 0.18-0.83), parents working in government agencies, enterprises, or institutions (OR=2.03, 95% CI: 1.06-3.86), parents engaged in social production and living services (OR=3.22, 95% CI: 1.40-7.40), and the influenza knowledge (OR=1.24, 95% CI: 1.08-1.44) were all correlated with childhood influenza vaccination status (P<0.05). Conclusions The childhood influenza vaccination rate still needs improvement, especially for special groups such as preterm infants; vaccine safety remains a major concern for parents.

Key words: influenza vaccine, inoculation, influencing factor, child

CLC Number:

JIA Ru, MA Yan, YU Qun, LIU Haiping, LIU Ping. An analysis of influenza vaccine coverage and influencing factors among children under 16 years old in two suburban districts of Shanghai[J].Journal of Clinical Pediatrics, 2026, 44(1): 31-37.

Figures/Tables 2

Table 1

Univariate analysis of factors related to influenza vaccination in children"

项目	接种组(n=14)	未接种组(n=14)	统计量	P
儿童情况
男性	133（46.3）	111（50.7）	χ²=0.94	0.369
年龄			χ²=11.48	0.022
<1岁	12（4.2）	12（5.5）
1~3岁	22（7.7）	15（6.8）
4~6岁	80（27.9）	48（21.9）
7~11岁	119（41.5）	76（34.7）
12~16岁	54（18.8）	68（31.1）
居住地			χ²=0.20	0.904
市区	207（72.1）	161（73.5）
郊区	61（21.3）	43（19.6）
农村	19（6.6）	15（6.8）
学校性质			χ²=0.01	1.000
公立	255（88.9）	195（89.0）
私立	32（11.1）	24（11.0）
既往疾病史			－	0.223¹⁾
无	267（93.0）	203（92.7）
哮喘	14（4.9）	7（3.2）
糖尿病	2（0.7）	0
短肠综合征	0	1（0.5）
系统性红斑狼疮	0	1（0.5）
先天性心脏病	2（0.7）	2（0.9）
癫痫	0	3（1.4）
其他	2（0.7）	2（0.9）
早产史	12（4.2）	21（9.6）	χ²=5.96	0.018
受试者情况
与儿童的关系			χ²=0.10	0.757
父亲	73（25.4）	53（24.2）
母亲	214（74.6）	166（75.8）
年龄			χ²=0.12	0.943
18~29岁	32（11.1）	25（11.4）
30~49岁	250（87.1）	191（87.2）
≥50岁	5（1.7）	3（1.4）
婚姻状况			χ²=4.46	0.108
未婚	2（0.7）	2（0.9）
已婚	280（97.6）	206（94.1）
离异	5（1.7）	11（5.0）
子女数			χ²=0.17	0.760
1个	209（72.8）	163（74.4）
≥2个	78（27.2）	56（25.6）
职业			χ²=15.44	0.017
无	22（7.7）	36（16.4）
机关、企业、事业单位	98（34.1）	66（30.1）
专业技术人员	42（14.6）	24（11.0）
医疗相关行业	79（27.5）	62（28.3）
社会生产生活服务人员	35（12.2）	16（7.3）
农林牧副渔人员	1（0.3）	1（0.5）
其他	10（3.5）	14（6.4）
文化程度			χ²=4.57	0.206
高中及以下	20（7.0）	19（8.7）
大专	53（18.5）	55（25.1）
本科	169（58.9）	118（53.9）
研究生及以上	45（15.7）	27（12.3）
家庭年收入			χ²=0.97	0.615
≤10万元	53（18.5）	41（18.7）
11~30万元	153（53.3）	108（49.3）
>30万元	81（28.2）	70（32.0）
流感知识认知分数	5（5~6）	5（4~6）	Z=3.48	0.001
流感疫苗知识认知分数	4（2~5）	3（1~5）	Z=2.84	0.005

Table 1

Table 2

References 30

[1]	国家免疫规划技术工作组流感疫苗工作组. 中国流感疫苗预防接种技术指南(2021—2022)[J]. 中华医学杂志, 2021, 101(40): 3287-3312.
[2]	World Health Organization. Seasonal influenza factsheet[EB/OL]. 2018 [2025-09-19]. https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
[3]	World Health Organization. Global influenza strategy 2019-2030 [EB/OL]. 2019 [2025-09-19]. https://apps.who.int/iris/handle/10665/311184.
[4]	中国疾病预防控制中心. 中国流感疫苗预防接种技术指南(2023-2024)[J]. 中国病毒病杂志, 2024, 14(1): 1-19.
	Chinese Center for Disease Control and Prevention. Technical guidelines for seasonal influenza vaccination in China, 2023-2024[J]. Zhongguo Bingdubing Zazhi, 2024, 14(1): 1-19.
[5]	Committee on Infectious Diseases. Recommendations for preventionand control of influenza in children, 2023-2024[J]. Pediatrics, 2023, 152(4): e2023063772.
[6]	Pepin S, Dupuy M, Borja-Tabora CFC, et al. Efficacy, immunogenicity, and safety of a quadrivalent inactivated influenza vaccine in children aged 6-35 months: a multi-season randomised placebo-controlled trial in the Northern and Southern Hemispheres[J]. Vaccine, 2019, 37(13): 1876-1884. doi: 10.1016/j.vaccine.2018.11.074
[7]	Seo J, Lim J. The impact of free vaccination policies under the Korean Influenza National Immunization Program: trends in influenza vaccination rates in South Korea from 2010 to 2019[J]. PLoS One, 2022, 17(1): e0262594.
[8]	Hill HA, Yankey D, Elam-Evans LD, et al. Vaccination coverage by age 24 months among children born in 2016 and 2017 - national immunization survey-child, United States, 2017-2019[J]. MMWR Morb Mortal Wkly Rep, 2020, 69(42): 1505-1511. doi: 10.15585/mmwr.mm6942a1
[9]	Hill HA, Yankey D, Elam-Evans LD, et al. Vaccination coverage by age 24 months among children born in 2017 and 2018-national immunization survey-child, United States, 2018-2020[J]. MMWR Morb Mortal Wkly Rep, 2021, 70(41): 1435-1440. doi: 10.15585/mmwr.mm7041a1
[10]	CDC. Flu vaccination coverage, United States, 2020-2021 influenza season[EB/OL]. 2022. https://www.cdc.gov/flu/fluvaxview/coverage-2021estimates.htm.
[11]	赵宏婷, 彭质斌, 倪兆林, 等. 2020—2021和2021—2022年度流感流行季我国流感疫苗接种政策和接种情况调查[J]. 中华预防医学杂志, 2022, 56(11): 1560-1564.
	Zhao HT, Peng ZB, Ni ZL, et al. Investigation on influenza vaccination policy and vaccination situation during the influenza seasons of 2020-2021 and 2021-2022 in China[J]. Zhonghua Yufang Yixue Zazhi, 2022, 56(11): 1560-1564.
[12]	蔡先明, 刘武, 赵春艳, 等. 我国两个地区儿童流感疫苗与肺炎疫苗接种现状与影响因素分析[J]. 中华流行病学杂志, 2023, 44(11): 1731-1737.
	Cai XM, Liu W, Zhao CY, et al. Study of coverage of influenza and pneumonia vaccinations in children and influencing factors in two areas, China[J]. Zhonghua Liuxingbingxue Zazhi, 2023, 44(11): 1731-1737.
[13]	Yan S, Wang Y, Zhu W, et al. Barriers to influenza vaccination among different populations in Shanghai[J]. Hum Vaccin Immunother, 2021, 17(5): 1403-1411. doi: 10.1080/21645515.2020.1826250
[14]	佘艳, 毛军, 邵海贤, 等. 上海市陆家嘴社区6月龄-6岁儿童流感疫苗的接种率及影响因素分析[J]. 上海医药, 2022, 43(6): 40-44.
	She Y, Mao J, Shao HX, et al. Analysis of the vaccination rate and influencing factors of influenza vaccine in children aged 6 months to 6 years old in Lujiazui Community of Shanghai[J]. Shanghai Yiyao, 2022, 43(6): 40-44.
[15]	杨孝坤, 王蕾, 赵宏婷, 等. 公众流感疫苗认知、接种现状及影响因素分析[J]. 实用预防医学, 2021, 28(6): 653-657.
	Yang XK, Wang L, Zhao HT, et al. Public cognition of influenza vaccine, current status of vaccination and its influencing factors[J]. Shiyong Yufang Yixue, 2021, 28(6): 653-657.
[16]	Committee on Infectious Diseases. Recommendations for prevention and control of influenza in children, 2024-2025: policy statement[J]. Pediatrics, 2024, 154(4): e2024068507.
[17]	李敏超, 陶晶, 张瑞, 等. 2023年浙江省幼托机构与小学儿童流感疫苗接种率的影响因素分析[J]. 上海预防医学, 2025, 37(1): 23-28.
	Li MC, Tao J, Zhang R, et al. Factors influencing influenza vaccination coverage among kindergarten and primary school children in Zhejiang Province, 2023[J]. Shanghai Yufang Yixue, 2025, 37(1): 23-28.
[18]	许妮娜, 龚玲, 罗家新. 新疆克拉玛依市克拉玛依区3-7岁儿童免费流感疫苗接种现状及影响因素分析[J]. 疾病预防控制通报, 2024, 39(3): 60-62.
[19]	Jorgensen P, Mereckiene J, Cotter S, et al. How close are countries of the WHO European Region to achieving the goal of vaccinating 75% of key risk groups against influenza? Results from national surveys on seasonal influenza vaccination programmes, 2008/2009 to 2014/2015[J]. Vaccine, 2018, 36(4): 442-452. doi: 10.1016/j.vaccine.2017.12.019
[20]	Stefanizzi P, Tafuri S, Bianchi FP. Immunogenicity of third dose of anti-SARS-CoV-2 vaccine co-administered with influenza vaccine: an open question[J]. Hum Vaccin Immunother, 2022, 18(6): 2094653. doi: 10.1080/21645515.2022.2094653
[21]	Chen H, Huang Z, Chang S, et al. Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV) coadministered with quadrivalent split-virion inactivated influenza vaccine and 23-valent pneumococcal polysaccharide vaccine in China: a multicentre, non-inferiority, open-label, randomised, controlled, phase 4 trial[J]. Vaccine, 2022, 40(36): 5322-5332. doi: 10.1016/j.vaccine.2022.07.033 pmid: 35931636
[22]	Sioriki AA, Gkentzi D, Papadimitriou E, et al. Vaccinations in infants born preterm: an update[J]. Curr Pediatr Rev, 2020, 16(2): 148-155. doi: 10.2174/1573396316666200116094459 pmid: 31951184
[23]	Chiappini E, Petrolini C, Sandini E, et al. Update on vaccination of preterm infants: a systematic review about safety and efficacy/effectiveness. Proposal for a position statement by Italian Society of Pediatric Allergology and Immunology jointly with the Italian Society of Neonatology[J]. Expert Rev Vaccines, 2019, 18(5): 523-545. doi: 10.1080/14760584.2019.1604230 pmid: 30952198
[24]	海峡两岸医药卫生交流协会新生儿学专业委员会新生儿循证医学学组. 早产儿支气管肺发育不良出院后随访管理专家共识[J]. 中国当代儿科杂志, 2022, 24(5):455-465.
	Neonatal Evidence-Based Medicine Group, Committee of Neonatal Medicine, Cross-Straits Medicine Exchange Association. Expert consensus on the follow-up management of bronchopulmonary dysplasia in preterm infants after discharge[J]. Zhongguo Dangdai Erke Zazhi, 2022, 24(5): 455-465.
[25]	Greenberg RG, Rountree W, Staat MA, et al. Apnea after 2-month vaccinations in hospitalized preterm infants: a randomized clinical trial[J]. JAMA Pediatr, 2025, 179(3): 246-254. doi: 10.1001/jamapediatrics.2024.5311 pmid: 39761016
[26]	国家卫生健康委员会. 国家免疫规划疫苗儿童免疫程序及说明(2021年版)[J]. 中国病毒病杂志, 2021, 11(4): 241-245.
	National Health Commission. Immunization schedules and instructions for vaccines of the national immunization program (2021 version)[J]. Zhongguo Bingdubing Zazhi, 2021, 11(4):241-245.
[27]	谭艳英, 葛桂平. 北京市通州区学龄前儿童流感疫苗接种现况及影响因素调查分析[J]. 中华养生保健, 2025, 43(2): 104-106.
[28]	李冬梅, 张霁颖, 史倩萍, 等. 2023—2024年流感季北京市大兴区6-<60月龄儿童流感疫苗接种率及其影响因素分析[J]. 中国病毒病杂志, 2025, 15(1): 66-72.
	Li DM, Zhang JY, Shi QP, et al. Analysis of influenza vaccination rates and influencing factors among children aged 6 to <60 months in Daxing district, Beijing, during the 2023-2024 influenza season[J]. Zhongguo Bingdubing Zazhi, 2025, 15(1): 66-72.
[29]	宋显相, 姜毅, 李温慈, 等. 温州市儿童家长对流感疫苗的接种意愿及影响因素分析[J]. 中国公共卫生管理, 2021, 37(5): 637-640.
	Song XX, Jiang Y, Li WC, et al. Analysis of parent's willingness to accept influenza vaccine and the influencing factors in Wenzhou City[J]. Zhongguo Gonggong Weisheng Guanli, 2021, 37(5): 637-640.
[30]	郭立春, 陈少伟, 冯海涛. 天津市西青区2023—2024年度流感季儿童流感疫苗接种状况[J]. 中国学校卫生, 2025, 46(2): 280-284.
	Guo LC, Chen SW, Feng HT. Influenza vaccination among children during the flu season of 2023-2024 in Xiqing District of Tianjin[J]. Zhongguo Xuexiao Weisheng, 2025, 46(2): 280-284.

因素	β	S.E.	χ²值	P	OR(95%CI)
早产史	－0.96	0.39	5.99	0.014	0.38（0.18~0.83）
机关、企业、事业单位¹⁾	0.71	0.33	4.60	0.032	2.03（1.06~3.86）
社会生产生活服务人员¹⁾	1.17	0.42	7.61	0.006	3.22（1.40~7.40）
流感知识认知分数	0.22	0.07	8.80	0.003	1.24（1.08~1.44）
常量	－1.77	0.59	9.09	0.003	－

An analysis of influenza vaccine coverage and influencing factors among children under 16 years old in two suburban districts of Shanghai

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