肠道菌群及其代谢产物在新生儿坏死性小肠结肠炎中研究现状与潜在应用思考

doi:10.12372/jcp.2022.22e0301

Abstract

Abstract:

The early prediction of necrotizing enterocolitis (NEC) by intestinal microbiota and its metabolites has been a hot research topic in recent years. Recent studies have found that infants with necrotizing enterocolitis (NEC) not only have low biodiversity of the intestinal microbiota, but also the composition proportion of microbiota is significantly different from that of healthy newborns. There are also abnormalities in amino acid, lipid metabolism and related metabolic enzymes in infants with NEC. Intestinal microbiota and its metabolites have certain value in predicting the onset and progression of NEC, but they can only be used as the basis for scientific research. High-quality, multi-center, and large-scale clinical studies are needed for clinical application in the future.

Key words: necrotizing enterocolitis, intestinal microbiota, metabolite, biomarker

LI Luquan, LIU Xiaochen. Research status and potential application of intestinal microbiota and its metabolites in neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatrics, 2022, 40(9): 654-660.

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Research status and potential application of intestinal microbiota and its metabolites in neonatal necrotizing enterocolitis

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