低场强MRI在儿科和产前胎儿诊断领域中的应用

doi:10.12372/jcp.2025.24e1182

临床儿科杂志 ›› 2025, Vol. 43 ›› Issue (9): 710-715.doi: 10.12372/jcp.2025.24e1182

低场强MRI在儿科和产前胎儿诊断领域中的应用

董素贞¹, 陈浩², 张志勇², 江帆³()

1.国家儿童医学中心上海交通大学医学院附属上海儿童医学中心放射科上海市儿童脑智发育重点实验室（上海 200127）
2.上海交通大学上海交通大学生物医学工程学院磁共振诊疗高端技术国家工程研究中心（上海 200030）
3.国家儿童医学中心上海交通大学医学院附属上海儿童医学中心发育行为儿科上海市儿童脑智发育重点实验室上海脑科学与类脑研究中心（上海 200127）

收稿日期:2024-11-05 录用日期:2025-02-06 出版日期:2025-09-15 发布日期:2025-08-27
通讯作者: 江帆电子信箱：fanjiang@shsmu.edu.cn
基金资助:
上海市儿童脑智发育重点实验室(24dz2260100)

Applications of low field MRI in pediatrics and prenatal fetal diagnosis

DONG Suzhen¹, CHEN Hao², ZHANG Zhiyong², JIANG Fan³()

1. Department of Radiology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, National Children’s Medical Center; Shanghai Key Laboratory of Child Brain and Development, Shanghai 200127, China
2. School of Biomedical Engineering; National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200030, China
3. Department of Developmental and Behavioral Pediatrics, Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, National Children’s Medical Center; Shanghai Key Laboratory of Child Brain and Development; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai 200127, China

Received:2024-11-05 Accepted:2025-02-06 Published:2025-09-15 Online:2025-08-27

摘要/Abstract

摘要：

磁共振成像（MRI）扫描仪的磁场强度越高，通常越能在更短时间内获得更高的信噪比与图像分辨率。然而，高场强 MRI 设备存在购置成本高昂、安装要求严苛、维护费用不菲等问题，使其难以广泛普及。相比之下，低场强 MRI 扫描仪因成本较低且具备便携性，已逐步应用于临床及相关科研工作。本文旨在综述低场强 MRI 扫描仪当前在儿科神经系统疾病、新生儿监护室及产前胎儿疾病中的诊断价值，并对其应用前景进行展望，以期全面阐释低场强 MRI 在胎儿及儿科诊断领域的应用价值与发展前景。

关键词: 磁共振成像, 胎儿, 产前诊断, 儿童

Abstract:

Generally, the higher the magnetic field strength of a magnetic resonance imaging (MRI) scanner, the greater the likelihood of achieving a higher signal-to-noise ratio and improved image resolution within a shorter scanning time. However, high-field-strength MRI systems are associated with significant limitations, including high acquisition costs, stringent installation requirements, and substantial maintenance expenditures, which collectively hinder their widespread adoption. In contrast, low-field-strength MRI scanners, due to their relatively lower costs and enhanced portability, have increasingly been integrated into clinical practice and related research settings. This review aims to summarize the current diagnostic applications of low-field-strength MRI in pediatric neurological disorders, neonatal intensive care, and prenatal fetal imaging, while also discussing their future potential. This article seeks to provide a comprehensive overview of the clinical value and developmental trajectory of low-field-strength MRI in fetal and pediatric diagnosis.

Key words: magnetic resonance imaging, fetus, prenatal diagnosis, child

中图分类号:

董素贞, 陈浩, 张志勇, 江帆. 低场强MRI在儿科和产前胎儿诊断领域中的应用[J]. 临床儿科杂志, 2025, 43(9): 710-715.

DONG Suzhen, CHEN Hao, ZHANG Zhiyong, JIANG Fan. Applications of low field MRI in pediatrics and prenatal fetal diagnosis[J]. Journal of Clinical Pediatrics, 2025, 43(9): 710-715.

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序列名称	扫描参数	扫描时间/min
快速自旋回波T1加权成像	重复时间(TR)，1 500 ms；回波时间(TE)，6 ms；反转时间(TI)，300 ms；分辨率 1.5 mm×1.5 mm×5 mm；36层	4:52
快速自旋回波T2加权成像	TR，2 200 ms；TE，253 ms；分辨率1.5 mm×1.5 mm×5 mm；36层	5:54
T2加权液体反转恢复成像	TR，4 000 ms；TE，228 ms；TI，1 400 ms；分辨率1.6 mm×1.6 mm×5 mm；36层	9:00
弥散加权成像	TR，1 000 ms；TE，100 ms；b=0,800 s/mm²；分辨率2.4 mm×2.4 mm×6 mm；30层	9:27

序列名称	扫描参数	扫描时间/s
快速自旋回波序列	TR，98 ms；TE，180 ms；FOV 350 mm×350 mm；Matrix 224×224；分辨率1.6 mm×1.6 mm×3 mm；30层	1:00
平衡稳态自由进动序列	TR，6.02 ms；TE, 3.01 ms；FOV 350 mm×350 mm；Matrix 192×192；分辨率1.8 mm×1.8 mm×3 mm；30层	0.45
实时电影序列	TR，570 ms；TE，1.82 ms；FOV 350 mm×350 mm；Matrix 128×128；分辨率2.8 mm×2.8 mm×10 mm；1层	0.6/层
快速T1加权成像	TR，113 ms；TE，2.43 ms；FOV 295 mm×350 mm；Matrix 138×192；分辨率1.8 mm×1.8 mm×4 mm；20层	16
弥散加权成像	TR，2 500 ms；TE，74 ms；FOV 294 mm×330 mm；Matrix 82×92；分辨率3.6 mm×3.6 mm×4 mm；20层；b=0,700 s/mm²；	30

低场强MRI在儿科和产前胎儿诊断领域中的应用

Applications of low field MRI in pediatrics and prenatal fetal diagnosis

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