临床儿科杂志 ›› 2023, Vol. 41 ›› Issue (9): 641-643.doi: 10.12372/jcp.2023.23e0639

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儿童脑病:一类与各种疾病都相关的疾病

邹丽萍   

  1. 中国人民解放军总医院儿科医学部(北京 1000853)
  • 收稿日期:2023-07-16 出版日期:2023-09-15 发布日期:2023-09-05

Childhood encephalopathy: a group of diseases associated with various diseases

ZOU Liping   

  1. Department of Pediatrics, PLA General Hospital, Beijing 1000853, China
  • Received:2023-07-16 Online:2023-09-15 Published:2023-09-05

摘要:

脑病是一种影响大脑结构和功能的严重且复杂的疾病,可导致严重的神经系统症状,甚至死亡,根据病程可分为急性脑病(急性脑功能障碍)和慢性脑病(慢性脑功能障碍)两类。急性脑病是一种由多种综合征组成的异质性疾病,可发生在任何年龄组,最常见于婴儿和学龄前儿童,可根据既往感染的病原体或生物学及临床病理特征分别进行分类,病因复杂多样,其中急性坏死性脑病是需要重点鉴别的脑病。儿童慢性脑病包括发育性脑病和家庭虐待所致的慢性创伤性脑病。脑病患儿可表现为认知障碍和语言发育迟缓、精神运动发育迟缓,或伴有惊厥等脑功能障碍的其他表现。遗传学检测是明确儿童慢性脑病病因的重要方法之一。文章介绍了脑病的不同病因及可能的临床症状,帮助临床医师早期识别诊断并给予及时有效的治疗。

关键词: 脑病, 神经系统, 脑功能障碍, 儿童

Abstract:

Encephalopathy is a serious and complex disease that affects the structure and function of the brain, which can cause severe neurological symptoms and even death. Encephalopathy can be divided into two types: acute encephalopathy (acute brain dysfunction) and chronic encephalopathy (chronic brain dysfunction). Acute encephalopathy is a heterogeneous disorder consisting of multiple syndromes that can occur in any age group, but is commonest in infants and preschoolers. Acute encephalopathy can be classified according to the pathogens of previous infections, or biological and clinicopathological features, and the etiology is complex and diverse. Among them, acute necrotizing encephalopathy needs to be identified. Chronic encephalopathy in children includes developmental encephalopathy and chronic traumatic encephalopathy in children with family abuse. Children with encephalopathy can show cognitive impairment, language retardation, psychomotor retardation, and other manifestations of brain dysfunction such as convulsions. Genetic testing is one of the important methods to help identify the cause of chronic encephalopathy in children. The article introduces the different etiology and possible clinical symptoms of encephalopathy to help clinicians diagnose early and give timely treatment.

Key words: encephalopathy, nervous system, brain dysfunction, child