儿童CAR-T细胞治疗的挑战与展望

doi:10.12372/jcp.2024.24e0578

摘要/Abstract

摘要：

嵌合抗原受体T细胞（CAR-T）首次应用于治疗急性淋巴细胞白血病复发患儿已有10年余，至今全世界范围内已有成千上万的患者从中受益，CAR-T细胞治疗在很大程度上提高了复发、难治儿童急性淋巴细胞白血病患者的整体预后，同时也正在逐渐改变着复发、难治儿童血液肿瘤患者的治疗历史。目前的研究显示，儿童CAR-T细胞治疗前景光明，但临床上仍面临着一些挑战。

关键词: 嵌合抗原受体T细胞, 挑战, 展望, 儿童

Abstract:

It has been more than 10 years since chimeric antigen receptor T cells (CAR-T) therapy were first used to treat children with relapsed acute lymphoblastic leukemia, and thousands of patients worldwide have benefited from it. CAR-T treatment has greatly improved the overall prognosis of relapsed and refractory pediatric acute lymphoblastic leukemia patients and is gradually changing the treatment history of relapsed and refractory pediatric hematological tumor patients. Currently, CAR-T treatment for children still faces some challenges, but overall, the prospects are extremely promising.

Key words: chimeric antigen receptor T cell, challenge, prospect, child

李本尚, 杨柳. 儿童CAR-T细胞治疗的挑战与展望[J]. 临床儿科杂志, 2024, 42(7): 573-577.

LI Benshang, YANG Liu. Challenges and prospects of CAR-T treatment for pediatric disease[J]. Journal of Clinical Pediatrics, 2024, 42(7): 573-577.

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