Journal of Clinical Pediatrics ›› 2026, Vol. 44 ›› Issue (7): 609-621.doi: 10.12372/jcp.2026.26e0788

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Core interpretation and explanation of Rome Ⅴ diagnostic criteria: lower and biliary disorders of gut-brain interaction in children and adolescents

Carlo Di Lorenzo1, Miguel Saps2, Bruno P. Chumpitazi3, Shaman Rajindrajith4, Annamaria Staiano5, Nikhil Thapar6,7, Miranda van Tilburg8, Carlos Velasco-Benítez9, Arine Vlieger (Author)10, Chinese Medical Association Parenteral and Enteral Nutrition Branch Pediatrics Group, The Subspecialty Group of Gastroenterology, The Society of Pediatric, Chinese Medical Association, Gastroenterology Group, Pediatrician Branch, Chinese Medical Doctor Association (Translator)   

  1. 1Nationwide Children’s Hospital, Columbus, Ohio
    2University of Miami, Miami, Florida
    3School of Medicine, Duke University, Durham, North Carolina
    4University of Colombo, Colombo, Sri Lanka
    5University of Naples Federico II, Naples, Italy
    6Queensland Children’s Hospital, Brisbane, Queensland, Australia
    7School of Medicine, University of Queensland, Brisbane, Queensland, Australia
    8School of Social Work, University of Washington, Seattle, Washington
    9Universidad del Valle ,Cali Colombia
    10St Antonius Hospital ,Nieuwegein, the Netherlands
  • Received:2026-06-10 Revised:2026-06-23 Accepted:2026-06-30 Published:2026-07-15 Online:2026-07-12

Abstract:

Rome V provides updated criteria for pediatric disorders of gut-brain interaction, replacing age-based subdivisions with a classiffcation based on the following regions and symptom patterns: abdominal pain disorders, defecation and anorectal disorders, and discomfort disorders. New entities were introduced, including biliary pain syndrome, centrally mediated abdominal pain syndrome, functional abdominal bloating, and proctalgia fugax. The term “infantile colic” has been replaced with “infant distress syndrome.” Existing criteria for irr itable bowel syndrome, functional constipation, and nonretentive fecal incontinence were revised to improve diagnostic clarity and reffect current clinical understanding. Rome V also acknowledges that disorders of gut-brain interaction may coexist with other conditions producing gastrointestinal symptoms. These updates are intended to support a more consistent diagnostic framework and guide appropriate management strategies for children and adolescents.

Key words: adolescents, disorders of gut-brain interaction, child

CLC Number: 

  • R72