胰高血糖素样肽-2类似物在炎症性肠病中的应用进展

doi:10.12372/jcp.2025.24e1343

Abstract

Abstract:

Glucagon-like peptide-2 is a polypeptide hormone secreted by intestinal L cells. It mainly exerts multiple physiological functions in the intestine, such as increasing blood flow, promoting nutrient absorption and enhancing barrier function, by binding to specific receptors. In the treatment of intestinal inflammation, GLP-2 has demonstrated multiple mechanisms including anti-inflammatory effects, promoting intestinal barrier repair and regulating the intestinal microbiota, and has achieved results in numerous animal experiments and clinical trials. This article summarizes the research progress of GLP-2 and its analogues in the treatment of inflammatory bowel disease, providing a basis for future research and clinical applications.

Key words: glucagon-like peptide-2, inflammatory bowel disease, Crohn’s disease, ulcerative colitis

CLC Number:

ZHOU Zhixuan, WANG Ying. Application progress of glucagon-like peptide-2 analogues in inflammatory bowel disease[J].Journal of Clinical Pediatrics, 2025, 43(9): 716-722.

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Application progress of glucagon-like peptide-2 analogues in inflammatory bowel disease

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