生长激素与肠道菌群相关性研究进展

doi:10.12372/jcp.2022.21e1593

摘要/Abstract

摘要：

人生长激素（hGH）由垂体前叶嗜酸性粒细胞合成，可通过胰岛素样生长因子-1（ IGF-1）对生长和代谢发挥作用。GH的缺乏或分泌不足导致的矮小症称为生长激素缺乏症（GHD），其具体病因及确切机制仍未完全阐释清楚。近年来，随着对肠道微生物菌群的认识及研究的深入，发现GH-IGF-1轴与肠道菌群存在相关性。文章就GH-IGF-1轴与肠道菌群关系的研究进行了阐述。

关键词: 生长激素, 矮小症, 生长激素缺乏症, 肠道菌群, 儿童

Abstract:

Human growth hormone (hGH), synthesized by eosinophils in the anterior pituitary gland, exerts effects on growth and metabolism through insulin-like growth factor-1 (IGF-1). Short stature caused by GH deficiency or insufficient secretion is called growth hormone deficiency (GHD), but its specific etiology and exact mechanism have not been fully explained. In recent years, with the in-depth understanding and research of gut microbiota, it has been found that the GH-IGF-1 axis is correlated with gut microbiota. This article reviews the research on the relationship between the GH-IGF-1 axis and the gut microbiota.

Key words: growth hormone, short stature, growth hormone deficiency, gut microbiota, child

石丽云, 王爱萍. 生长激素与肠道菌群相关性研究进展[J]. 临床儿科杂志, 2022, 40(12): 955-959.

SHI Liyun, WANG Aiping. Research progress on the correlation between growth hormone and gut microbiota[J]. Journal of Clinical Pediatrics, 2022, 40(12): 955-959.

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