儿童听觉事件相关电位正常参考值构建的初步探索

doi:10.12372/jcp.2025.25e0814

临床儿科杂志 ›› 2025, Vol. 43 ›› Issue (12): 915-921.doi: 10.12372/jcp.2025.25e0814

儿童听觉事件相关电位正常参考值构建的初步探索

魏林¹, 沈佳丽¹, 马孝宝¹, 汪玮¹, 王璐¹, 金玉莲¹, 杨军¹, 郑贵亮¹, 楼高忠², 赵哲弘³, 陈建勇¹()

1.上海交通大学医学院附属新华医院耳鼻咽喉头颈外科上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室（上海 200092）
2.杭州市妇幼保健院（杭州市儿童医院）耳鼻咽喉科（浙江杭州 310006）
3.绍兴市中心医院医共体总院耳鼻咽喉科（浙江绍兴 312030）

收稿日期:2025-07-11 录用日期:2025-09-22 出版日期:2025-12-15 发布日期:2025-11-28
通讯作者: 陈建勇电子信箱：chenjianyong@xinhuamed.com.cn
基金资助:
国家自然科学基金面上项目(82271179);国家自然科学基金面上项目(82230035);国家自然科学基金面上项目(82271160);国家重点研发计划(2024YFC2511100);上海交通大学医学院附属新华医院院级临床研究培育基金项目(21XHDB02)

Preliminary exploration on establishment of normal reference value for auditory event related potentials in children

WEI Lin¹, SHEN Jiali¹, MA Xiaobao¹, WANG Wei¹, WANG Lu¹, JIN Yulian¹, YANG Jun¹, ZHENG Guiliang¹, LOU Gaozhong², ZHAO Zhehong³, CHEN Jianyong¹()

1. Department of Otolaryngology, Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease, Shanghai 200092, China
2. Department of Otolaryngology, Hangzhou Maternal and Child Health Care Hospital, Hangzhou Children's Hospital, Hangzhou 310006, Zhejiang, China
3. Department of Otolaryngology, General Hospital of Medical Community, Shaoxing Central Hospital, Shaoxing 312030, Zhejiang, China

Received:2025-07-11 Accepted:2025-09-22 Published:2025-12-15 Online:2025-11-28

摘要/Abstract

摘要：

目的建立6~17岁正常儿童听觉事件相关电位（AERPs）中P1、N1、P2、N2、P3各成分的临床参考值范围，为临床儿童相关疾病致认知功能损伤的评估提供临床参考。方法选取2024年1月至2025年1月在听力障碍及眩晕诊治中心就诊的听力正常的健康儿童作为研究对象，应用听觉Oddball范式进行AERPs测试。比较儿童双耳AERPs各波形成分差异，建立AERPs各波形成分潜伏期和振幅正常值。结果最终纳入28名（56耳）6~17岁听力正常的健康儿童，平均年龄（8.75±2.40）岁，男15名（30耳）、女13名（26耳）。儿童AERPs各波形成分的正常潜伏期为：P1（56.00±13.11）ms、N1（106.36±15.26）ms、P2（183.29±26.77）ms、N2（229.21±26.28）ms、P3（329.89±22.32）ms，95%置信区间（CI）分别为：P1（30.29~81.71）ms、N1（76.44~136.27）ms、P2（130.82~235.75）ms、N2（177.71~280.72）ms、P3（286.14~373.64）ms；振幅值分别为：P1[6.91(4.91~10.92)]μV、P1-N1[9.26(4.82~14.79)]μV、N1-P2[9.90(5.60~14.25)]μV、P2-N2[6.21(4.40~9.94)]μV、N2-P3[10.68(5.95~15.81)]μV；95%CI分别为：P1(5.37~10.43)μV、P1-N1(6.06~11.79)μV、N1-P2(6.96~12.98)μV、P2-N2(5.20~8.80)μV、N2-P3(9.15~14.93)μV。结论本研究初步建立了6~17岁儿童AERPs各成分正常参考值，有助于为临床儿童认知功能损伤的评估提供数据支持。

关键词: 听觉事件相关电位, 正常参考值, 认知功能, 儿童

Abstract:

Objective To establish a range of clinical reference values for each component of P1, N1, P2, N2, and P3 in auditory event related potentials (AERPs) in normal children aged 6-17 years, and to provide an assessment of cognitive impairments caused by clinically relevant diseases in children. Methods Healthy children with normal hearing who visited the Diagnosis and Treatment Center for Hearing Impairment and Vertigo between January 2024 and January 2025 were selected as study participants. AERPs were recorded using the auditory Oddball paradigm. Differences in AERP waveform components between both ears were compared, and normative values for the latency and amplitude of each AERP component were established. Results A total of 28 healthy children (56 ears) with normal hearing aged 6 to 17 years were included, with an average age of (8.75±2.40) years, including 15 boys (30 ears) and 13 girls (26 ears). The normal latency of each wave component of AERP in children is as follows: P1 (56.00±13.11) ms, N1 (106.36±15.26) ms, P2 (183.29±26.77) ms, N2 (229.21±26.28) ms and P3 (329.89±22.32) ms. The 95% confidence intervals (CI) are: P1 (30.29-81.71) ms, N1 (76.44-136.27) ms, P2 (130.82-235.75) ms, N2 (177.71-280.72) ms, and P3 (286.14-373.64) ms. The amplitude values are as follows: P1 [6.91 (4.91 - 10.92)] μV, P1-N1 [9.26 (4.82 - 14.79)] μV, N1-P2 [9.90 (5.60-14.25)] μV, P2-N2 [6.21 (4.40-9.94)] μV and N2-P3 [10.68 (5.95-15.81)] μV; 95% confidence intervals are: P1 (5.37-10.43) μV, P1-N1 (6.06-11.79) μV, N1-P2 (6.96-12.98) μV, P2-N2 (5.20-8.80) μV and N2-P3 (9.15-14.93) μV. Conclusions This study initially established the normal reference values of each component of AERPs for children aged 6 to 17, which is helpful in providing data support for the clinical assessment of cognitive function impairment in children.

Key words: auditory event-related potentials, normative reference value, cognitive function, child

中图分类号:

魏林, 沈佳丽, 马孝宝, 汪玮, 王璐, 金玉莲, 杨军, 郑贵亮, 楼高忠, 赵哲弘, 陈建勇. 儿童听觉事件相关电位正常参考值构建的初步探索[J]. 临床儿科杂志, 2025, 43(12): 915-921.

WEI Lin, SHEN Jiali, MA Xiaobao, WANG Wei, WANG Lu, JIN Yulian, YANG Jun, ZHENG Guiliang, LOU Gaozhong, ZHAO Zhehong, CHEN Jianyong. Preliminary exploration on establishment of normal reference value for auditory event related potentials in children[J]. Journal of Clinical Pediatrics, 2025, 43(12): 915-921.

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AERPs各成分	侧别	耳数	潜伏期($\bar{x}±s$)/ms	t值	P
P1	右	28	57.71±21.55	0.66	0.513
	左	28	54.29±15.95	0.66	0.513
N1	右	28	107.07±22.41	0.28	0.786
	左	28	105.64±18.52	0.28	0.786
P2	右	28	186.93±31.35	1.26	0.219
	左	28	179.64±30.31	1.26	0.219
N2	右	28	229.64±33.16	0.14	0.889
	左	28	228.79±28.32	0.14	0.889
P3	右	28	327.71±20.40	1.07	0.294
	左	28	332.07±28.50	1.07	0.294

AERPs各成分	侧别	耳数	振幅[M(P₂₅~P₇₅)]/μV	Z值	P
P1	右	28	8.41(4.5~11.97)	1.14	0.255
	左	28	6.45(2.6~11.99)	1.14	0.255
N1	右	28	7.68(4.39~12.86)	0.59	0.554
	左	28	8.49(4.15~14.12)	0.59	0.554
P2	右	28	9.03(3.59~16.05)	0.02	0.982
	左	28	9.31(4.61~16.93)	0.02	0.982
N2	右	28	6.06(2.78~10.48)	0.66	0.509
	左	28	6.87(3.91~13.55)	0.66	0.509
P3	右	28	9.70(4.13~19.26)	0.16	0.873
	左	28	9.66(5.23~16.13)	0.16	0.873

儿童听觉事件相关电位正常参考值构建的初步探索

Preliminary exploration on establishment of normal reference value for auditory event related potentials in children

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