川崎病冠状动脉损伤机制免疫遗传研究进展

doi:10.12372/jcp.2023.21e1773

摘要/Abstract

摘要：

川崎病（KD）是以全身性血管炎为主要特征的儿童常见疾病，其最严重的并发症即累及冠状动脉的心血管疾病，即使治疗后，也有部分儿童遗留冠状动脉瘤等后遗症。川崎病已成为儿童获得性心脏病最常见原因之一。目前KD冠状动脉损伤的机制尚不清晰。文章从免疫遗传方向综述国内外KD冠状动脉损伤机制最新研究成果与进展。

关键词: 川崎病, 冠状动脉, 基因, 儿童

Abstract:

Kawasaki disease (KD) is a kind of common diseases in children mainly characterized by systemic vasculitis. The most serious complication of KD is cardiovascular disease involving coronary arteries. Even after treatment, some children still have sequelae such as coronary aneurysms. KD has become one of the most common causes of acquired heart disease in children. At present, the pathogenesis of KD coronary artery injury is not clear. From the perspective of immunogenetics, the latest research results and progress of coronary artery injury mechanism of KD are reviewed in the article.

Key words: Kawasaki disease, coronary artery, gene, child

邱佳韵（综述）, 周国平（审校）. 川崎病冠状动脉损伤机制免疫遗传研究进展[J]. 临床儿科杂志, 2023, 41(1): 66-72.

Reviewer: QIU Jiayun, Reviser: ZHOU Guoping. Immune genetics of coronary artery injury pathogenesis in Kawasaki disease[J]. Journal of Clinical Pediatrics, 2023, 41(1): 66-72.

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