以下肢动脉血栓为首发表现的儿童系统性红斑狼疮合并抗磷脂综合征2例报告

doi:10.12372/jcp.2026.25e1528

Abstract

Abstract:

To summarize clinical characteristics, treatment and prognosis of lower extremity arterial thrombosis caused by systemic lupus erythematosus (SLE) complicated with antiphospholipid syndrome (APS) in children, and to provide diagnostic and therapeutic experience for clinicians. Two cases of lower extremity arterial thrombosis caused by SLE complicated with APS were collected.The differences in clinical characteristics, treatment plans and prognosis were compared and analyzed between two cases. Patient 1 was treated with glucocorticoids, cyclophosphamide, belimumab, intravenous immunoglobulins, hydroxychloroquine and anticoagulation drug. However, gangrene still occurred, resulting in necrosis and eventual auto-amputation of toe bones. During a follow-up of 4 years, no thrombotic events recurred. Patient 2 was treated with glucocorticoids, rituximab, hydroxychloroquine, anticoagulation drug, balloon dilation, catheter-directed thrombolysis and thrombus aspiration. The patient had a good prognosis after 9 months of follow-up. Children with SLE complicated by APS may develop lower extremity arterial thrombosis, which carries a risk of serious adverse outcomes. Early diagnosis and active treatment are crucial.

Key words: lower extremity arterial thrombosis, systemic lupus erythematosus, antiphospholipid syndrome, child

CLC Number:

CHU Weihong, XU Liyan, PENG Shao, LAI Jianming. Lower extremity arterial thrombosis as first clinical manifestation in children's systemic lupus erythematosus complicated with antiphospholipid syndrome: a two-case report[J].Journal of Clinical Pediatrics, 2026, 44(6): 579-583.

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References 15

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Lower extremity arterial thrombosis as first clinical manifestation in children's systemic lupus erythematosus complicated with antiphospholipid syndrome: a two-case report

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