婴幼儿重症百日咳研究进展

doi:10.12372/jcp.2025.24e0793

摘要/Abstract

摘要：

百日咳具有高度的传染性，随着近几年百日咳发病率的上升，有些地区甚至出现百日咳暴发。百日咳再现问题引起了广泛关注，其中重症百日咳对婴幼儿的生命健康造成极大威胁。白细胞计数升高、肺动脉高压、未接种疫苗及混合感染等与重症百日咳发生相关。由于婴幼儿患者早期缺乏典型的临床症状与体征，未能得到及时的诊治，很容易发展为重症百日咳，因此对百日咳做出准确诊断和及时治疗至关重要。本文对婴幼儿重症百日咳的发病机制、治疗以及预防进行综述，以深化临床医师对重症百日咳的认识，为重症百日咳的防治提供参考。

关键词: 重症百日咳, 发病机制, 疫苗, 婴幼儿

Abstract:

Pertussis is highly contagious. With the increase in the incidence rate of pertussis in recent years, pertussis outbreaks have even occurred in some areas. The recurrence of pertussis has attracted widespread attention, among which severe pertussis poses a great threat to the life and health of infants and young children. Elevated white blood cell count, pulmonary hypertension, non-vaccination and mixed infection are all associated with severe pertussis. Due to the lack of typical clinical symptoms and signs in infants and young children in the early stage, they often fail to receive timely diagnosis and treatment, which can easily lead to severe pertussis. Therefore, it is crucial to make an accurate diagnosis and provide timely treatment for pertussis. This article reviews the pathogenesis, treatment and prevention of severe pertussis in infants and young children, in order to deepen the clinician's understanding of severe pertussis and provide reference for the prevention and treatment of severe pertussis.

Key words: severe pertussis, pathogenesis, vaccine, infants and young children

许示沂, 杜敏, 白丽霞, 刘爱红. 婴幼儿重症百日咳研究进展[J]. 临床儿科杂志, 2025, 43(5): 383-388.

XU Shiyi, DU Min, BAI Lixia, LIU Aihong. Research progress on severe pertussis in infants and young children[J]. Journal of Clinical Pediatrics, 2025, 43(5): 383-388.

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